Document Detail

Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors.
MedLine Citation:
PMID:  17719728     Owner:  NLM     Status:  MEDLINE    
Transmembrane bound receptors comprised of extracellular immunoglobulin (Ig) or lectin domains play integral roles in a large number of immune functions including inhibitory and activating responses. The function of many of the activating receptors requires a physical interaction with an adaptor protein possessing a cytoplasmic regulatory motif. The partnering of an activating receptor with an adaptor protein relies on complementary charged residues in the two transmembrane domains. The mammalian natural killer (NK) and Fc receptors (FcR) represent two of many receptor families, which possess activating receptors that partner with adaptor proteins for signaling. Zebrafish represent a powerful experimental model for understanding developmental regulation at early stages of embryogenesis and for efficiently generating transgenic animals. In an effort to understand developmental aspects of immune receptor function, we have accessed the partially annotated zebrafish genome to identify six different adaptor molecules: Dap10, Dap12, Cd3zeta, Cd3zeta-like, FcRgamma and FcRgamma-like that are homologous to those effecting immune function in mammals. Their genomic organizations have been characterized, cDNA transcripts have been recovered, phylogenetic relationships have been defined and their cell lineage-specific expression patterns have been established.
Jeffrey A Yoder; Timothy M Orcutt; David Traver; Gary W Litman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-07-27
Journal Detail:
Title:  Gene     Volume:  401     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-10-24     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  154-64     Citation Subset:  IM    
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/EF158445;  EF158446;  EF158447;  EF158448;  EF601085;  EF601086
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MeSH Terms
Adaptor Proteins, Signal Transducing / chemistry*,  genetics,  metabolism*
Amino Acid Sequence
Antigens, CD3 / genetics,  metabolism
Cell Lineage
Cell Membrane / immunology,  metabolism
Cloning, Molecular
DNA, Complementary
Embryo, Nonmammalian
Gene Expression Regulation, Developmental
Killer Cells, Natural / immunology
Molecular Sequence Data
Protein Structure, Tertiary
Receptors, IgG / immunology
Receptors, Immunologic / chemistry*,  genetics,  metabolism*
Receptors, KIR
Sequence Homology, Amino Acid
Zebrafish / embryology*,  genetics
Zebrafish Proteins
Grant Support
R01 AI057559/AI/NIAID NIH HHS; R01 AI057559/AI/NIAID NIH HHS; R01 AI057559-02/AI/NIAID NIH HHS; R01 AI057559-03/AI/NIAID NIH HHS
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Antigens, CD3; 0/CD3 antigen, zeta chain; 0/DNA, Complementary; 0/Dap12 protein, zebrafish; 0/Receptors, IgG; 0/Receptors, Immunologic; 0/Receptors, KIR; 0/Zebrafish Proteins

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