| Structural change of adrenocortical adenoma in Cushing's syndrome. | |
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MedLine Citation:
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PMID: 3766136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight adrenocortical adenomata from patients with Cushing's syndrome were examined by light and electron microscopy. Light microscopically, the reticulin fibers were markedly prominent in areas of the compact-type cells and ran tangentially to the adenoma cells or parenchymal cells. Electron microscopically, adrenocortical adenoma was composed of parenchymal cells, interstitial cells, and endothelial cells. In areas of the clear-type cells, the parenchymal cells were arranged in long columns and covered by the sinusoidal wall. In areas of the compact-type cells, the sinusoid was well-developed and meandering. The dilated intercellular space was conspicuous and filled with filamentous substance and collagen fibrils. The parenchymal cells appeared to produce the filamentous substance and collagen fibrils, and underwent fragmentation. Interstitial cells and fragmented cytoplasm of the parenchymal cells were found in the intercellular and perisinusoidal space. It was likely that the fragmented cytoplasm flowed into the sinusoid. Experimental study using cell culture methods revealed these phenomena, especially a production of collagen fibrils. |
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Authors:
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K Matsuo; H Tsuchiyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta pathologica japonica Volume: 36 ISSN: 0001-6632 ISO Abbreviation: Acta Pathol. Jpn. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-11-12 Completed Date: 1986-11-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372637 Medline TA: Acta Pathol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 879-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
/
complications,
pathology*,
ultrastructure Adrenal Cortex Neoplasms / complications, pathology*, ultrastructure Adult Aged Cushing Syndrome / etiology, pathology* Female Humans Microscopy, Electron Microscopy, Electron, Scanning Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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