Document Detail

Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8.
MedLine Citation:
PMID:  20553865     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Maternal infection during pregnancy has been repeatedly associated with increased risk for schizophrenia. Nevertheless, most viruses do not cross the placenta; therefore, the damaging effects to the fetus appear to be related to maternal antiviral responses to infection (e.g. proinflammatory cytokines). Fetal exposure to the proinflammatory cytokine interleukin-8 (IL-8) has been significantly associated with risk of schizophrenia in offspring. This study sought to determine the association between fetal exposure to IL-8 and structural brain changes among schizophrenia cases and controls.
METHODS: Subjects were 17 cases diagnosed with schizophrenia from the Developmental Insult and Brain Anomaly in Schizophrenia (DIBS) study. Psychiatric diagnoses were determined among offspring with semi-structured interviews and medical records review. IL-8 was determined from assays in archived prenatal sera and volumetric analyses of neuroanatomical regions were obtained from T1-weighted magnetic resonance imaging in adulthood. Eight controls were included for exploratory purposes.
RESULTS: Among cases, fetal exposure to increases in IL-8 was associated with significant increases in ventricular cerebrospinal fluid, significant decreases in left entorhinal cortex volumes and significant decreases in right posterior cingulate volumes. Decreases that approached significance also were found in volumes of the right caudate, the putamen (bilaterally), and the right superior temporal gyrus. No significant associations were observed among controls.
CONCLUSION: Fetal exposure to elevations in maternal IL-8 led to structural neuroanatomic alterations among cases in regions of the brain consistently implicated in schizophrenia research. In utero exposure to elevations in IL-8 may partially account for brain disturbances commonly found in schizophrenia.
Lauren M Ellman; Raymond F Deicken; Sophia Vinogradov; William S Kremen; John H Poole; David M Kern; Wei Yann Tsai; Catherine A Schaefer; Alan S Brown
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-06-09
Journal Detail:
Title:  Schizophrenia research     Volume:  121     ISSN:  1573-2509     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-08     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  46-54     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
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MeSH Terms
Brain / growth & development,  pathology*
Cohort Studies
Cytokines / metabolism
Image Processing, Computer-Assisted / methods
Interleukin-8 / adverse effects*,  cerebrospinal fluid
Magnetic Resonance Imaging / methods
Prenatal Diagnosis / methods
Prenatal Exposure Delayed Effects / cerebrospinal fluid,  etiology*,  pathology*
Schizophrenia / drug therapy
Grant Support
5 T32 MH018870-20/MH/NIMH NIH HHS; K02 MH065422/MH/NIMH NIH HHS; K02 MH065422-01A2/MH/NIMH NIH HHS; K02MH065422-06/MH/NIMH NIH HHS; K05 DA022413/DA/NIDA NIH HHS; N01HD13334/HD/NICHD NIH HHS; N01HD63258/HD/NICHD NIH HHS; R01 AG018386/AG/NIA NIH HHS; R01 AG022381/AG/NIA NIH HHS; R01 MH060249/MH/NIMH NIH HHS; R01 MH060249-01A2/MH/NIMH NIH HHS; R01 MH063264/MH/NIMH NIH HHS; R01 MH063264-01A1/MH/NIMH NIH HHS; R01MH060249/MH/NIMH NIH HHS; R01MH63264/MH/NIMH NIH HHS; T32 MH018870/MH/NIMH NIH HHS; T32 MH018870-20/MH/NIMH NIH HHS
Reg. No./Substance:
0/Cytokines; 0/Interleukin-8
Comment In:
Expert Rev Neurother. 2011 Jan;11(1):29-32   [PMID:  21158552 ]

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