Document Detail

Structural birth defects associated with oral clefts in Hawaii, 1986 to 2001.
MedLine Citation:
PMID:  16681409     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify structural birth defects that occur in association with oral clefts. METHODS: Data were obtained from a birth defects registry and included all infants and fetuses with cleft palate without cleft lip or cleft lip with or without cleft palate delivered from 1986 to 2001. For 47 specific structural birth defects, rates among oral cleft cases were compared with the rates among all infants and fetuses with major birth defects, excluding those with oral clefts. RESULTS: Among cleft palate only cases, the rates were significantly higher than expected for encephalocele, microcephaly, and syndactyly. Among cases of cleft lip with or without cleft palate, the rates were significantly higher than expected for anophthalmia/microphthalmia, single ventricle, reduction deformity of upper limbs, and reduction deformity of lower limbs. When cases of cleft palate only and cleft lip with or without cleft palate were compared as to the rates for particular birth defects, the rates of the defects were either higher or lower than expected in both oral cleft categories for 38 (81%) of the defects. CONCLUSIONS: Certain birth defects were more frequently associated with oral clefts than might be expected. For the majority of defects, their patterns of association were similar between cleft palate without cleft lip and cleft lip with or without cleft palate.
Mathias B Forrester; Ruth D Merz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  43     ISSN:  1055-6656     ISO Abbreviation:  Cleft Palate Craniofac. J.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-09     Completed Date:  2006-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  356-62     Citation Subset:  D; IM    
Hawaii Birth Defects Program, Honolulu, Hawaii 96817-5157, USA.
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MeSH Terms
Anophthalmos / complications
Cleft Lip / complications*
Cleft Palate / complications*
Encephalocele / complications
Heart Defects, Congenital / complications
Infant, Newborn
Limb Deformities, Congenital / complications
Microcephaly / complications
Retrospective Studies
Syndactyly / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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