| Structural and biophysical insight into cholesteryl ester-transfer protein. | |
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MedLine Citation:
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PMID: 21787337 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data. |
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Authors:
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Justin Hall; Xiayang Qiu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical Society transactions Volume: 39 ISSN: 1470-8752 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 1000-5 Citation Subset: IM |
Affiliation:
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Pfizer Research and Development, Eastern Point Road, Groton, CT 06430, U.S.A. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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