Document Detail


Structural biology of type VI secretion systems.
MedLine Citation:
PMID:  22411981     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Type VI secretion systems (T6SSs) are transenvelope complexes specialized in the transport of proteins or domains directly into target cells. These systems are versatile as they can target either eukaryotic host cells and therefore modulate the bacteria-host interaction and pathogenesis or bacterial cells and therefore facilitate access to a specific niche. These molecular machines comprise at least 13 proteins. Although recent years have witnessed advances in the role and function of these secretion systems, little is known about how these complexes assemble in the cell envelope. Interestingly, the current information converges to the idea that T6SSs are composed of two subassemblies, one resembling the contractile bacteriophage tail, whereas the other subunits are embedded in the inner and outer membranes and anchor the bacteriophage-like structure to the cell envelope. In this review, we summarize recent structural information on individual T6SS components emphasizing the fact that T6SSs are composite systems, adapting subunits from various origins.
Authors:
Eric Cascales; Christian Cambillau
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  367     ISSN:  1471-2970     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-06-26     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1102-11     Citation Subset:  IM    
Affiliation:
CNRS, Laboratoire d'Ingénierie des Systèmes Macromoléculaires, UMR 7255, Institut de Microbiologie de la Méditerranée, Aix-Marseille Université, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France. cascales@imm.cnrs.fr
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / chemistry*
Bacterial Secretion Systems*
Cell Membrane / chemistry
Escherichia coli / chemistry
Escherichia coli Proteins / chemistry
Lipopeptides / chemistry
Membrane Proteins / chemistry
Models, Molecular
Molecular Chaperones / chemistry
Multiprotein Complexes / chemistry*
Periplasm / chemistry
Protein Folding
Protein Structure, Tertiary
Protein Transport
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Escherichia coli Proteins; 0/Lipopeptides; 0/Membrane Proteins; 0/Molecular Chaperones; 0/Multiprotein Complexes; 0/TssJ protein, E coli
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