Document Detail


Structural biology of the membrane attack complex.
MedLine Citation:
PMID:  24798009     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The complement system is an intricate network of serum proteins that mediates humoral innate immunity through an amplification cascade that ultimately leads to recruitment of inflammatory cells or opsonisation or killing of pathogens. One effector arm of this network is the terminal pathway of complement, which leads to the formation of the membrane attack complex (MAC) composed of complement components C5b, C6, C7, C8 and C9. Upon formation of C5 convertases via the classical or alternative pathways of complement activation, C5b is generated from C5 by proteolytic cleavage, nucleating a series of association and polymerisation reactions of the MAC-constituting complement components that culminate in pore formation of pathogenic membranes. Recent structures of MAC components and homologous proteins significantly increased our understanding of oligomerisation, membrane association and integration, shedding light onto the molecular mechanism of this important branch of the innate immune system.
Authors:
Andreas F-P Sonnen; Philipp Henneke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sub-cellular biochemistry     Volume:  80     ISSN:  0306-0225     ISO Abbreviation:  Subcell. Biochem.     Publication Date:  2014  
Date Detail:
Created Date:  2014-05-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0316571     Medline TA:  Subcell Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-116     Citation Subset:  IM    
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