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Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates.
MedLine Citation:
PMID:  21796301     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.
Authors:
Aman Iqbal; Ian J Clifton; Rasheduzzaman Chowdhury; David Ivison; Carmen Domene; Christopher J Schofield
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-28
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, U.K.. Christopher.schofield@chemistry.oxford.ac.uk.
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