Document Detail


Structural basis of single molecular heparin-FX06 interaction revealed by SPM measurements and molecular simulations.
MedLine Citation:
PMID:  23147065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heparin, a functionalized polysaccharide, is observed under a scanning tunneling microscope, which shows atomic scale conformational details. The peptide FX06 is found to bind to five consecutive sugar units of heparin and this interaction is directly revealed by atomic force microscopy and dynamic force spectroscopy measurements. The determined free energy change agrees well with the dynamic calculation result.
Authors:
Cunlan Guo; Bin Wang; Lianchun Wang; Bingqian Xu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  48     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-22     Completed Date:  2013-05-06     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  12222-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Fibrin Fibrinogen Degradation Products / chemistry*,  metabolism*
Heparin / chemistry*,  metabolism*
Microscopy, Atomic Force
Models, Molecular*
Peptide Fragments / chemistry*,  metabolism*
Protein Binding
Protein Conformation
Grant Support
ID/Acronym/Agency:
GM103390/GM/NIGMS NIH HHS; P41 RR005351/RR/NCRR NIH HHS; R01 HL093339/HL/NHLBI NIH HHS; R01HL093339/HL/NHLBI NIH HHS; RR005351/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/fibrinogen Bbeta (15-42); 9005-49-6/Heparin
Comments/Corrections

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