| Structural basis of influenza virus neutralization. | |
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MedLine Citation:
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PMID: 21251008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although seasonal influenza vaccines play a valuable role in reducing the spread of virus at the population level, ongoing viral evolution to evade immune responses remains problematic. No current vaccines elicit enduring protection in the face of emerging and re-emerging influenza viruses that are rapidly undergoing antigenic drift. Eliciting broadly cross-neutralizing antibody (nAb) responses against influenza virus is a crucial goal for seasonal and pandemic influenza vaccine preparation. Recent three-dimensional structure information obtained from crystallization of influenza antigens in complex with nAbs has provided a framework for interpreting antibody-based viral neutralization that should aid in the design of vaccine immunogens. Here, we will review current knowledge of the structure-based mechanisms contributing to the neutralization and neutralization escape of influenza viruses. We will also explore the potential for this structure-based approach to overcome the obstacles in developing the highly desired "universal" influenza vaccine. |
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Authors:
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Thomas Han; Wayne A Marasco |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-01-11 |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1217 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-03-10 Revised Date: 2013-06-04 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 178-90 Citation Subset: IM |
Copyright Information:
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© 2011 New York Academy of Sciences. |
Affiliation:
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Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Neutralizing / physiology* Humans Influenza Vaccines / chemical synthesis, immunology Influenza, Human / immunology*, prevention & control*, virology Neutralization Tests / methods, trends Orthomyxoviridae / growth & development, immunology*, pathogenicity* |
| Grant Support | |
ID/Acronym/Agency:
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1K01AI073861/AI/NIAID NIH HHS; P41 RR-01081/RR/NCRR NIH HHS; U01 AI074518/AI/NIAID NIH HHS; U01 AI074518-03/AI/NIAID NIH HHS; U01-AI074518-01/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Neutralizing; 0/Influenza Vaccines |
| Comments/Corrections | |
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