Document Detail

Structural basis for airflow limitation in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  11033839     Owner:  NLM     Status:  MEDLINE    
The airflow limitation that characterises chronic obstructive pulmonary disease (COPD) has two main components: an increased resistance, which is due to airway obstruction, and a loss of the elastic recoil pressure of the lung, which is due to parenchymal destruction. Although it has long been known that the major site of increased resistance in COPD is the peripheral airways, recent studies have shown that central airways are involved in the disease as well. The purpose of this review is to describe the major structural and cellular changes present in peripheral airways, central airways and lung parenchyma of patients with COPD, and to underline the possible mechanisms contributing to airflow limitation in these subjects.
M Saetta; G Turato; R Zuin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders     Volume:  17     ISSN:  1124-0490     ISO Abbreviation:  Sarcoidosis Vasc Diffuse Lung Dis     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-12     Completed Date:  2001-01-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9610928     Medline TA:  Sarcoidosis Vasc Diffuse Lung Dis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
Dipartimento di Medicina Ambientale e Sanità Pubblica, Università degli Studi di Padova, Italy.
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MeSH Terms
Airway Resistance*
Lung Diseases, Obstructive / pathology*,  physiopathology*
Pulmonary Emphysema / pathology*,  physiopathology
Pulmonary Gas Exchange
Severity of Illness Index
Smoking / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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