| Structural bases for the chemical regulation of Connexin43 channels. | |
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MedLine Citation:
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PMID: 15094347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Connexins proteins associate with a variety of catalytic and non-catalytic molecules. Also, different domains of connexin can bind to each other, providing a mechanism for channel regulation. Here, we review some of these associations, placing particular emphasis on the intramolecular interactions that regulate Connexin43 (Cx43). We also describe some novel methods that allow for the characterization of protein-protein interactions such as those observed in the cardiac gap junction protein Connexin43. Overall, intra- and inter-molecular interactions may regulate gap junctions to filter the passage of molecular messages between cells at the appropriate time and between the appropriate cells. As a potential area for future investigations, we also speculate as to whether some of the inter-molecular interactions involving connexins lead to modifications in the function of the associated protein, rather than on the function of connexin itself. |
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Authors:
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Mario Delmar; Wanda Coombs; Paul Sorgen; Heather S Duffy; Steven M Taffet |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiovascular research Volume: 62 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-19 Completed Date: 2004-09-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 268-75 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, SUNY Upstate Medical University, 766 Irving Ave, Syracuse, NY 13210, USA. delmarm@upstate.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication Cell Membrane Permeability Connexin 43 / chemistry*, genetics, metabolism Gap Junctions / metabolism* Gene Expression Regulation Humans Hydrogen-Ion Concentration Ion Channel Gating Myocardium / metabolism Protein Binding Protein Structure, Tertiary |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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