Document Detail


Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling.
MedLine Citation:
PMID:  16877548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several animal models of atrial fibrillation (AF) have been developed that demonstrate either atrial structural remodeling or atrial electrical remodeling, but the characteristics and spatiotemporal organization of the AF between the models have not been compared. Thirty-nine dogs were divided into five groups: rapid atrial pacing (RAP), chronic mitral regurgitation (MR), congestive heart failure (CHF), methylcholine (Meth), and control. Right and left atria (RA and LA, respectively) were simultaneously mapped during episodes of AF in each animal using high-density (240 electrodes) epicardial arrays. Multiple 30-s AF epochs were recorded in each dog. Fast Fourier transform was calculated every 1 s over a sliding 2-s window, and dominant frequency (DF) was determined. Stable, discrete, high-frequency areas were seen in none of the RAP or control dogs, four of nine MR dogs, four of six CHF dogs, and seven of nine Meth dogs in either the RA or LA or both. Average DFs in the Meth model were significantly greater than in all other models in both LA and RA except LA DFs in the RAP model. The RAP model was the only one with a consistent LA-to-RA DF gradient (9.5 +/- 0.2 vs. 8.3 +/- 0.3 Hz, P < 0.00005). The Meth model had a higher spatial and temporal variance of DFs and lower measured organization levels compared with the other AF models, and it was the only model to show a linear relationship between the highest DF and dispersion (R(2) = 0.86). These data indicate that structural remodeling of atria (models known to have predominantly altered conduction) leads to an AF characterized by a stable high-frequency area, whereas electrical remodeling of atria (models known to have predominantly shortened refractoriness without significant conduction abnormalities) leads to an AF characterized by multiple high-frequency areas and multiple wavelets.
Authors:
Thomas H Everett; Emily E Wilson; Sander Verheule; Jose M Guerra; Scott Foreman; Jeffrey E Olgin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-07-28
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  291     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-08     Completed Date:  2007-01-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H2911-23     Citation Subset:  IM    
Affiliation:
Cardiac Electrophysiology, University of California-San Francisco, CA 94143-1354, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / pathology,  physiopathology
Atrial Fibrillation / pathology*,  physiopathology*
Atrial Function, Left / physiology
Atrial Function, Right / physiology
Choline / adverse effects,  analogs & derivatives
Disease Models, Animal
Dogs
Electrocardiography
Electrophysiology
Fourier Analysis
Heart Atria / innervation*,  pathology,  physiopathology*
Heart Failure / pathology,  physiopathology
Mitral Valve Insufficiency / pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
5R01-HL-072854/HL/NHLBI NIH HHS; R01 HL072854-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/methylcholine; 62-49-7/Choline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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