Document Detail


Structural alterations in adult rat carotid bodies exposed to hyperbaric oxygenation.
MedLine Citation:
PMID:  21226393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
METHODS: Twenty-one adult male Wistar rats, divided into three groups, were maintained in room air or exposed to O2 at 2.4 or 3.0 ATA for six hours. Histological, ultrastructural and immunohistochemical analyses for neuronal nitric oxide synthase (nNOS) and F2-isoprostane were performed in the excised CBs.
RESULTS: Histological analyses revealed signs of intracellular edema in animals exposed to both conditions, but this was more marked in the 3.0 ATA group, which showed ultrastructural alterations at the mitochondrial level. There was a significant increase in the volume density of intraglomic-congested capillaries in the 3.0 ATA group associated with an arteriolar vasoconstriction. In the 2.4 ATA group, there was a relative increase of glomic light cells and a decrease of glomic progenitor cells. Additionally, there was a stronger immunoreactivity for F2-isoprostane in the 3.0 ATA O2-exposed carotid bodies. The glomic cells stained positive for nNOS, but no difference was observed between the groups. Our results show that high O2 exposures may induce structural alterations in glomic cells with signs of lipid peroxidation. We further suggest that deviation of blood flow toward intraglomic capillaries occurs in hyperbaric hyperoxia.
Authors:
M S Leite; N R Damaceno-Rodrigues; M R P T Simone; A B G Santos; H M S Bueno; C N Battlehner; T Mauad; E G Caldini; P H N Saldiva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc     Volume:  37     ISSN:  1066-2936     ISO Abbreviation:  Undersea Hyperb Med     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2011-01-13     Completed Date:  2011-01-24     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9312954     Medline TA:  Undersea Hyperb Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  419-32     Citation Subset:  IM; S    
Affiliation:
Experimental Air Pollution Laboratory, Department of Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil. magnochi@bol.com.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / pathology
Capillaries / pathology
Carotid Body / metabolism,  physiopathology,  ultrastructure*
Edema / etiology
F2-Isoprostanes / metabolism
Hyperbaric Oxygenation / adverse effects*
Immunohistochemistry / methods
Lipid Peroxidation
Male
Mitochondria / ultrastructure
Nitric Oxide Synthase Type I / metabolism
Oxidative Stress
Rats
Rats, Wistar
Vasoconstriction
Chemical
Reg. No./Substance:
0/F2-Isoprostanes; EC 1.14.13.39/Nitric Oxide Synthase Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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