Document Detail


Structural airway abnormalities in infants and young children with cystic fibrosis.
MedLine Citation:
PMID:  14760252     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine whether the airway structure of infants and young children with cystic fibrosis (CF) differs from that of normal children by using high-resolution computed tomography (HRCT) imaging. Study design Full-inflation, controlled ventilation HRCT images of the lungs were obtained at four anatomic levels in 34 infants with CF (age, 2.4+/-1.4 years) and 20 control infants (age, 1.8+/-1.4 years). Short axis diameters of all clearly identifiable, round airway/vessel pairs were measured to obtain airway wall thickness (AWT), airway lumen diameter (ALD), and vessel diameter (VD). RESULTS: In infants with CF, mean AWT (+/-SD) was 0.58+/-0.13 mm, ALD was 1.31+/-0.56 mm, and VD was 1.62+/-0.58 mm. In control infants, mean AWT was 0.49+/-0.13 mm, ALD was 1.07+/-0.42 mm, and VD was 1.86+/-0.64 mm. Mean AWT and ALD were greater in children with CF than in normal subjects (P<.001). ALD:VD ratios increased with age in patients with CF compared with control subjects (P=.026). CONCLUSIONS: The airways of infants and young children with CF have thicker walls and are more dilated than those of normal infants.
Authors:
Frederick R Long; Roger S Williams; Robert G Castile
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  144     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-04     Completed Date:  2004-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  AIM; IM    
Affiliation:
Children's Radiological Institute, Children's Hospital, Department of Pediatrics, Ohio State University School of Medicine and Public Health, Children's Hospital and Children's Research Institute, Columbus, Ohio 43205-2696, USA. Flong@chi.osu.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Bronchi / pathology*
Bronchiectasis / radiography*
Case-Control Studies
Child, Preschool
Cystic Fibrosis / pathology*,  radiography
Dilatation, Pathologic / radiography
Female
Humans
Infant
Male
Observer Variation
Positive-Pressure Respiration / methods
Pulmonary Artery / pathology*,  radiography
Pulmonary Veins / pathology,  radiography
Tomography, X-Ray Computed / methods
Comments/Corrections
Comment In:
J Pediatr. 2004 Feb;144(2):145-6   [PMID:  14760248 ]

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