| Structural airway abnormalities in infants and young children with cystic fibrosis. | |
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MedLine Citation:
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PMID: 14760252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine whether the airway structure of infants and young children with cystic fibrosis (CF) differs from that of normal children by using high-resolution computed tomography (HRCT) imaging. Study design Full-inflation, controlled ventilation HRCT images of the lungs were obtained at four anatomic levels in 34 infants with CF (age, 2.4+/-1.4 years) and 20 control infants (age, 1.8+/-1.4 years). Short axis diameters of all clearly identifiable, round airway/vessel pairs were measured to obtain airway wall thickness (AWT), airway lumen diameter (ALD), and vessel diameter (VD). RESULTS: In infants with CF, mean AWT (+/-SD) was 0.58+/-0.13 mm, ALD was 1.31+/-0.56 mm, and VD was 1.62+/-0.58 mm. In control infants, mean AWT was 0.49+/-0.13 mm, ALD was 1.07+/-0.42 mm, and VD was 1.86+/-0.64 mm. Mean AWT and ALD were greater in children with CF than in normal subjects (P<.001). ALD:VD ratios increased with age in patients with CF compared with control subjects (P=.026). CONCLUSIONS: The airways of infants and young children with CF have thicker walls and are more dilated than those of normal infants. |
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Authors:
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Frederick R Long; Roger S Williams; Robert G Castile |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 144 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-04 Completed Date: 2004-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 154-61 Citation Subset: AIM; IM |
Affiliation:
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Children's Radiological Institute, Children's Hospital, Department of Pediatrics, Ohio State University School of Medicine and Public Health, Children's Hospital and Children's Research Institute, Columbus, Ohio 43205-2696, USA. Flong@chi.osu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Bronchi / pathology* Bronchiectasis / radiography* Case-Control Studies Child, Preschool Cystic Fibrosis / pathology*, radiography Dilatation, Pathologic / radiography Female Humans Infant Male Observer Variation Positive-Pressure Respiration / methods Pulmonary Artery / pathology*, radiography Pulmonary Veins / pathology, radiography Tomography, X-Ray Computed / methods |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2004 Feb;144(2):145-6
[PMID:
14760248
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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