Document Detail

Structural abnormality of the substantia nigra in children with attention-deficit hyperactivity disorder.
MedLine Citation:
PMID:  20040247     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Structural abnormality of the substantia nigra can be detected by transcranial sonography in neuropsychiatric disorders such as Parkinson disease and restless legs syndrome. We investigated echogenicity of the substantia nigra as a potential structural marker for dysfunction of the nigrostriatal dopamine system in children with attention-deficit hyperactivity disorder (ADHD). METHODS: We used a blinded design and determined echogenicity of the substantia nigra by use of transcranial sonography in 22 children with ADHD and 22 healthy controls matched for age and sex. RESULTS: The echogenic substantia nigra area was significantly larger in ADHD patients than in healthy controls (F(1,42) = 9.298, p = 0.004, effect size = 0.92). We found no effects of age or sex. LIMITATIONS: Owing to a lack of dimensional assessment, we could not analyze the correlation between echogenicity and clinical symptoms. CONCLUSION: Our results support the hypothesis that the nigrostriatal dopaminergic system is abnormal in children with ADHD.
Marcel Romanos; David Weise; Mira Schliesser; Martin Schecklmann; Julia Löffler; Andreas Warnke; Manfred Gerlach; Joseph Classen; Claudia Mehler-Wex
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psychiatry & neuroscience : JPN     Volume:  35     ISSN:  1488-2434     ISO Abbreviation:  J Psychiatry Neurosci     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-30     Completed Date:  2010-03-01     Revised Date:  2010-09-28    
Medline Journal Info:
Nlm Unique ID:  9107859     Medline TA:  J Psychiatry Neurosci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  55-8     Citation Subset:  IM    
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, Wuerzburg, Germany.
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MeSH Terms
Age Factors
Analysis of Variance
Attention Deficit Disorder with Hyperactivity / epidemiology,  pathology,  ultrasonography*
Organ Size
Sex Factors
Substantia Nigra / abnormalities*,  pathology,  ultrasonography
Ultrasonography, Doppler, Transcranial

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