| Structural abnormalities of the trigeminal root revealed by diffusion tensor imaging in patients with trigeminal neuralgia caused by neurovascular compression: a prospective, double-blind, controlled study. | |
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MedLine Citation:
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PMID: 21835547 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Because diffusion tensor imaging (DTI) is able to assess tissue integrity, we used diffusion to detect abnormalities in trigeminal nerves (TGN) in patients with trigeminal neuralgia (TN) caused by neurovascular compression (NVC). We also studied anatomical TGN parameters (cross-sectional area [CSA] and volume [V]). Using DTI sequencing in a 3-T magnetic resonance imaging (MRI) scanner, we measured the fraction of anisotropy (FA) and the apparent diffusion coefficient (ADC) of TGN in 10 patients selected as candidates to have microvascular decompression (MVD) for TN, and 6 normal control subjects. We compared data between the affected nerves of TN (ipsilateral TN), unaffected nerves of TN (contralateral TN), and both nerves in normal subjects (controls), and correlated these data with CSA and V. The FA of the ipsilateral TN (0.37±0.08) was significantly lower (P<.05) compared with the contralateral TN (0.48±0.08) and control values (0.52±0.04). The ADC of ipsilateral TN (5.6±0.89mm(2)/s) was significantly higher (P<.05) compared with the contralateral TN (4.26±0.59mm(2)/s) and control values (3.84±0.43mm(2)/s). Ipsilateral TN had less V and CSA compared with contralateral TN and control values (P<.05). The Spearman correlation coefficient showed a strong positive correlation between loss of FA and loss of V (r=0.7576) and loss of CSA (r=0.9273) of affected nerves. The Spearman correlation coefficient showed a strong negative correlation between increase in ADC and loss of V (r=-0.7173) and loss of CSA (r=-0.7416) in affected nerves. DTI revealed alteration in the FA and ADC values of the affected TGN. These alterations were correlated with atrophic changes in patients with TN caused by NVC. |
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Authors:
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Paulo Roberto Lacerda Leal; Jean Amédée Roch; Marc Hermier; Miguel Angelo Nobre Souza; Gerardo Cristino-Filho; Marc Sindou |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-9 |
Journal Detail:
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Title: Pain Volume: - ISSN: 1872-6623 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7508686 Medline TA: Pain Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurosurgery, University of Lyon 1, Lyon, France; Department of Neurosurgery, Faculty of Medicine of Sobral, Federal University of Ceará, Sobral, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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