Document Detail


Structural abnormalities of the thalamus in juvenile myoclonic epilepsy.
MedLine Citation:
PMID:  21700499     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Studies have suggested that the thalamus is a key structure in the pathophysiology of juvenile myoclonic epilepsy. The objective of the present investigation was to examine the thalami of patients with juvenile myoclonic epilepsy using a combination of multiple structural neuroimaging modalities. The association between these techniques may reveal the mechanisms underlying juvenile myoclonic epilepsy and help to identify the neuroanatomical structures involved. Twenty-one patients with juvenile myoclonic epilepsy (13 women, mean age=30±9years) and a control group of 20 healthy individuals (10 women, mean age=31±8years) underwent MRI in a 2-T scanner. The volumetric three-dimensional sequence was used for structural investigation. Evaluation of the thalamus comprised voxel-based morphometry, automatic volumetry, and shape analysis. Comparisons were performed between patient and control groups. Voxel-based morphometry analysis identified areas of atrophy located in the anterior portion of the thalamus. Post hoc analysis of automatic volumetry did not reveal significant differences between the groups. Shape analysis disclosed differences between patients and controls in the anterior and inferior portions of the right thalamus and in the anterior portion of the left thalamus. The present investigation confirms that thalami of patients with juvenile myoclonic epilepsy are structurally abnormal with impairments located mainly in the anterior and inferior sections.
Authors:
Susana Barreto Mory; Luiz E Betting; Paula T Fernandes; Iscia Lopes-Cendes; Marilisa M Guerreiro; Carlos A M Guerreiro; Fernando Cendes; Li M Li
Related Documents :
19429719 - Leukotriene b4 contributes to exhaled breath condensate and sputum neutrophil chemotaxi...
20390069 - The site of airway obstruction among patients of emphysema: role of impulse oscillometry.
15625609 - Physiotherapy in obstructive sleep apnea syndrome: preliminary results.
22732299 - Thyroid scintigraphy: an old tool is still the gold standard for an effective diagnosis...
11488329 - Exhaled nitric oxide in chronic obstructive pulmonary disease: relationship to pulmonar...
21547609 - Polyomavirus jc reactivation and noncoding control region sequence analysis in pediatri...
17050329 - Clinical, andrological and genetic characteristics of patients with congenital bilatera...
11535519 - Decreased von willebrand factor protease activity associated with thrombocytopenic diso...
1680449 - Experience with subcutaneous erythropoietin in capd patients.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-22
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  -     ISSN:  1525-5069     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute pain crisis as a presentation of primary megaureter in children.
Next Document:  Hyperammonemic encephalopathy related to valproate, phenobarbital, and topiramate synergism.