Document Detail

Structural abnormalities remote from the seizure focus: a study using T2 relaxometry at 3 T.
MedLine Citation:
PMID:  15623691     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the extent and severity of mesial temporal and subcortical signal abnormalities in patients with partial epilepsy. METHODS: T2 relaxation time maps were acquired in 50 consecutive patients and 55 control subjects on a 3 T MRI scanner. Twenty-two patients had hippocampal sclerosis (HS), 16 had malformations of cortical development (MCD), and 12 had no obvious MR abnormalities (normal MR). The following eight regions were measured bilaterally: hippocampus, anterior temporal lobe (ATL) white matter, amygdala, frontal lobe white matter, caudate, putamen, pallidum, and thalamus. RESULTS: In patients with HS, increased T2 relaxation times were found in the ipsilateral hippocampus and ATL but not in subcortical nuclei. In patients with MCD, increased T2 relaxation times were found in the temporal lobe (hippocampus, ATL) and in subcortical areas (caudate, putamen, and pallidum); in patients with normal MR, increased T2 relaxation times were found in the hippocampus and putamen. The degree of abnormality did not correlate with the duration of epilepsy or the estimated seizure load. CONCLUSIONS: Mesial temporal structures show increased T2 relaxation times not only in patients with hippocampal sclerosis but also in patients with a seizure focus remote from the hippocampus. Patients with normal MR and focal malformations of cortical development have increased T2 relaxation times in subcortical structures. Therefore, abnormalities in T2 relaxation time can be found remote from the seizure focus. They cannot be simply attributed to secondary seizure effects.
R S Briellmann; G D Jackson; G S Pell; L A Mitchell; D F Abbott
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  63     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-29     Completed Date:  2005-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2303-8     Citation Subset:  AIM; IM    
Brain Research Institute, Austin Health, Melbourne, Australia.
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MeSH Terms
Basal Ganglia / pathology
Brain / abnormalities,  pathology*
Epilepsies, Partial / pathology*
Hippocampus / pathology
Magnetic Resonance Imaging / methods*
Organ Specificity
Preoperative Care
Single-Blind Method
Temporal Lobe / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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