Document Detail


Structural abnormalities of the central auditory pathway in infants with non-syndromic cleft lip and/or palate.
MedLine Citation:
PMID:  21848367     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To investigate possible structural abnormalities of the central auditory pathway in infants with non-syndromic cleft lip and/or palate (NSCL/P). Participants: Twenty seven Chinese infants with NSCL/P, aged from 6 to 24 months. Intervention: Morphological magnetic resonance imaging (MRI) measurements of the central auditory nervous system (CANS) in infants with NSCL/P were analyzed and compared with age and sex matched normal controls. Results: No significant group differences were found in general brain measurements, including volumes of the brain stem and right hemisphere. However, infants with NSCL/P had statistically significantly smaller volumes of the left thalamus and left auditory cortex and notably decreased thickness of the left auditory cortex. Conclusion: Cortical abnormalities were more marked compared with other MRI measurements. Structural CANS abnormalities in infants with NSCLP may mainly be located in the left cerebral hemisphere. The development and maturation of the auditory cortex in infants with NSCLP may be abnormal when compared with that of normal children. Key Words: central auditory nervous system, cleft lip and palate, hearing impairment, magnetic resonance imaging.
Authors:
Frank Feng Yang; Bradley McPherson; Huang Shu; Na Xie; Kui Xiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-17
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  -     ISSN:  1545-1569     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Center for Communication Disorders, Speech and Hearing Sciences, the University of Hong Kong.
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