| Structural studies of the Sputnik virophage. | |
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MedLine Citation:
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PMID: 19889775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The virophage Sputnik is a satellite virus of the giant mimivirus and is the only satellite virus reported to date whose propagation adversely affects its host virus' production. Genome sequence analysis showed that Sputnik has genes related to viruses infecting all three domains of life. Here, we report structural studies of Sputnik, which show that it is about 740 A in diameter, has a T=27 icosahedral capsid, and has a lipid membrane inside the protein shell. Structural analyses suggest that the major capsid protein of Sputnik is likely to have a double jelly-roll fold, although sequence alignments do not show any detectable similarity with other viral double jelly-roll capsid proteins. Hence, the origin of Sputnik's capsid might have been derived from other viruses prior to its association with mimivirus. |
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Authors:
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Siyang Sun; Bernard La Scola; Valorie D Bowman; Christopher M Ryan; Julian P Whitelegge; Didier Raoult; Michael G Rossmann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-11-04 |
Journal Detail:
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Title: Journal of virology Volume: 84 ISSN: 1098-5514 ISO Abbreviation: J. Virol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-23 Completed Date: 2010-01-12 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 894-7 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907-2054, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acanthamoeba
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virology* Animals Capsid / chemistry Cryoelectron Microscopy Crystallization Imaging, Three-Dimensional Mass Spectrometry Mimiviridae / chemistry, genetics, ultrastructure* Satellite Viruses / chemistry, genetics, ultrastructure* Virion / chemistry, ultrastructure |
| Grant Support | |
ID/Acronym/Agency:
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AI11219/AI/NIAID NIH HHS; R37 AI011219-40/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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