| Structural and functional magnetic resonance imaging of the human cerebellar nuclei. | |
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MedLine Citation:
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PMID: 20665253 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present review focuses on recent developments in structural and functional magnetic resonance imaging (MRI) of the deep cerebellar nuclei (DCN), the main output structure of the cerebellum. The high iron content in the DCN allows for their visibility in T2*-weighted images. Spatial resolution has improved allowing the identification of DCN in individual cerebellar patients and healthy subjects. Based on findings in larger groups of healthy subjects, probabilistic MRI-based atlases of the deep cerebellar nuclei have been developed, which are important tools in human lesion and functional imaging studies. High iron content in the DCN, on the other hand, decreases the blood oxygenation level dependent-signal making functional imaging a difficult challenge. Compared to the vast amount of studies reporting activation of the cerebellar cortex, the number of studies demonstrating activation of the DCN is much less. Most studies report activation of the dentate nucleus. Dentate activations appear to be more reliable in more complex tasks for reasons currently unknown. As yet, few studies tried to show activations of functional subunits of the dentate nucleus. Increased signal-to-noise ratio and better spatial resolution using higher MR field strength together with recent progress in dentate normalization methods will allow identification of functional subunits and their interactions with the cerebellar cortex in future studies. |
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Authors:
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Michael Küper; Markus Thürling; Stefan Maderwald; Mark E Ladd; Dagmar Timmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cerebellum (London, England) Volume: 11 ISSN: 1473-4230 ISO Abbreviation: Cerebellum Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101089443 Medline TA: Cerebellum Country: United States |
Other Details:
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Languages: eng Pagination: 314-24 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany, Michael.kueper@uni-due.de. |
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