| Structural features of ischemic damage in the hippocampus. | |
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MedLine Citation:
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PMID: 19943345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral ischemic injury resulting from either focal or global circulatory arrests in the brain is one of the major causes of death and disability in the adult population. The hippocampus, playing important roles in learning and memory, is selectively vulnerable to ischemic insults. Distinct populations of hippocampal neurons are targeted by ischemia and multiple factors, including excitotoxicity, oxidative stress, and inflammation, are responsible for their damage and death. Modifications of synapses occur very early after ischemia, reflecting related changes in synaptic transmission. These modifications structurally relate to spatial patterns formed by synaptic vesicles, geometry of postsynaptic density, and so forth. Ischemia-induced changes of synaptic contacts can be implicated in the mechanisms leading to delayed neuronal death. In this review, we summarize the available data on the structural aspects of ischemic injury of the hippocampus obtained in tissue culture and animal models and discuss pathways of neurodegeneration common for cerebral ischemia and various neurodegenerative disorders. |
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Authors:
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Alexander G Nikonenko; Lidija Radenovic; Pavle R Andjus; Galyna G Skibo |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anatomical record (Hoboken, N.J. : 2007) Volume: 292 ISSN: 1932-8494 ISO Abbreviation: Anat Rec (Hoboken) Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-03 Completed Date: 2010-02-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101292775 Medline TA: Anat Rec (Hoboken) Country: United States |
Other Details:
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Languages: eng Pagination: 1914-21 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Bogomoletz Institute of Physiology, Bogomoletz street 4, Kiev, Ukraine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Infarction / pathology*, physiopathology Brain Ischemia / pathology*, physiopathology Cells, Cultured Disease Models, Animal Encephalitis / etiology, pathology, physiopathology Hippocampus / pathology*, physiopathology Humans Nerve Degeneration / etiology, pathology*, physiopathology Oxidative Stress / physiology Synapses / metabolism, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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