| Structural determination and daily variations of porcine milk oligosaccharides. | |
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MedLine Citation:
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PMID: 20369835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Free milk oligosaccharides (OS) are major components of mammalian milk. Swine are important agricultural species and biomedical models. Despite their importance, little is known of the OS profile of porcine milk. Herein, the porcine milk glycome was elucidated and monitored over the entire lactation period by liquid chromatography profiling and structural determination with mass spectrometry. Milk was collected from second-parity sows (n = 3) at farrowing and on days 1, 4, 7, and 24 of lactation. Twenty-nine distinct porcine milk oligosaccharides (pMO) were identified. The pMO are highly sialylated, which is more similar to bovine milk than human milk OS. Six fucosylated pMO were detected at low levels in porcine milk, making it more similar to human milk than bovine milk. In general, the pMO content was highest in milk collected at farrowing and day 1 of lactation, decreased during early lactation, but then rose at day 24; however, the pMO displayed different patterns of variation across lactation. In summary, porcine milk contains both acidic (sialylated) and neutral OS, but sialic acid containing OS predominate throughout lactation. |
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Authors:
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Nannan Tao; Karen L Ochonicky; J Bruce German; Sharon M Donovan; Carlito B Lebrilla |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-07-26 Revised Date: 2012-04-25 |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 4653-9 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Biochemistry (School of Medicine), University of California, Davis, California 95616, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbohydrate Conformation Chromatography, Liquid Milk / chemistry* Oligosaccharides / analysis, chemistry* Swine |
| Grant Support | |
ID/Acronym/Agency:
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HD061923/HD/NICHD NIH HHS; R01 049077//PHS HHS; R01 GM049077-16S1/GM/NIGMS NIH HHS; R01 GM049077-16S2/GM/NIGMS NIH HHS; R01 GM049077-17/GM/NIGMS NIH HHS; R01 HD-061929/HD/NICHD NIH HHS; R01 HD061923/HD/NICHD NIH HHS; R01 HD061923-01/HD/NICHD NIH HHS; R01 HD061923-02/HD/NICHD NIH HHS; R01 HD061923-03/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Oligosaccharides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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