Document Detail

Structural characterization of polysaccharides from Zizyphus jujuba and evaluation of antioxidant activity.
MedLine Citation:
PMID:  20615429     Owner:  NLM     Status:  MEDLINE    
Fruit of Zizyphus jujuba Mill, a traditional Chinese herb widely consumed in Asian countries, has been reported to possess several vital biological activities. This study intends to develop an appropriate analytical method for isolation of polysaccharides from Z. jujuba fruits and evaluate their antioxidant activity. Initially, powdered Z. jujuba fruits were subjected to hot water extraction, followed by ethanol precipitation, deproteination, dialysis and fractionation in a DEAE-Sepharose CL-6B column. One neutral polysaccharide fraction (ZJPN) and 3 acidic polysaccharide fractions (ZJPa1, ZJPa2 and ZJPa3) were isolated with the average MW ranging from 40,566 to 129,518 Da. GC analysis revealed that 6 monosaccharides, namely, rhamnose, arabinose, xylose, mannose, glucose and galactose were present in polysaccharide fractions. The galacturonic acid content in polysaccharide fractions followed the order: ZJPa3>ZJPa2>ZJPa1>ZJPN. All the 4 polysaccharide fractions were found to be more effective in scavenging superoxide anions than hydroxyl radicals, while acidic polysaccharides showed a more pronounced effect in chelating ferrous ion.
S C Chang; B Y Hsu; B H Chen
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Publication Detail:
Type:  Journal Article     Date:  2010-07-06
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  47     ISSN:  1879-0003     ISO Abbreviation:  Int. J. Biol. Macromol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  445-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Department of Food Science, Fu Jen University, Taipei 242, Taiwan.
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MeSH Terms
Antioxidants / pharmacology*
Chromatography, Gas
Chromatography, Ion Exchange
Free Radical Scavengers / pharmacology
Hexuronic Acids / analysis
Hydroxyl Radical / metabolism
Iron Chelating Agents / pharmacology
Molecular Weight
Polysaccharides / analysis,  chemistry*
Reference Standards
Spectroscopy, Fourier Transform Infrared
Superoxides / metabolism
Ziziphus / chemistry*
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 0/Hexuronic Acids; 0/Ions; 0/Iron Chelating Agents; 0/Polysaccharides; 11062-77-4/Superoxides; 14982-50-4/galacturonic acid; 3352-57-6/Hydroxyl Radical

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