Document Detail

Structural Changes of the Heart During Severe Sepsis or Septic Shock.
MedLine Citation:
PMID:  22301606     Owner:  NLM     Status:  Publisher    
ABSTRACT: Cardiovascular dysfunction is common in severe sepsis or septic shock. Although functional alterations are often described, the elevated serum levels of cardiac proteins and autopsy findings of myocardial immune cell infiltration, edema and damaged mitochondria suggest that structural changes to the heart during severe sepsis and septic shock may occur and may contribute to cardiac dysfunction. We explored the available literature on structural (vs functional) cardiac alterations during experimental and human endotoxaemia and/or sepsis. Limited data suggests that the structural changes could be prevented and myocardial function improved by (pre-) treatment with platelet activating factor (PAF), ciclosporin A (CsA), glutamine, caffeine, simvastatin or caspase inhibitors.
Lonneke Smeding; Frans B Plötz; A B Johan Groeneveld; Martin C J Kneyber
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-31
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  -     ISSN:  1540-0514     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
(1) Department of Pediatrics, division of Pediatric Intensive Care, VU university medical center, Amsterdam, The Netherlands; (2) Institute for Cardiovascular Research (ICaR-VU), VU university medical center, Amsterdam, The Netherlands; (3) Department of Pediatrics, Tergooi Hospital, Blaricum, The Netherlands; (4) Department of Intensive Care, VU university medical center, Amsterdam, The Netherlands; (5) Department of Intensive Care, ErasmusMC, Rotterdam, The Netherlands; (6) Department of Pediatrics, division of Pediatric Intensive Care, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands.
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