Document Detail


Structural analysis of tethered bilayer lipid membranes.
MedLine Citation:
PMID:  20504013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Solid supported membrane systems have been established as biomimetic architectures, which allow for the systematic investigation of various membrane-related processes. Especially tethered bilayer lipid membranes have been a successful concept. They consist of a lipid bilayer that is covalently anchored to a solid substrate through a spacer group. The submembrane part, which is defined by the spacer group, is important especially for the biological activity of incorporated membrane proteins. Anchor lipids with different spacer and anchor groups have been synthesized, and the resulting membrane structures have been investigated by neutron reflectivity. The different molecular architectures had a significant effect on both the amount of water incorporated in the spacer region and the electrical properties of the bilayer. A detailed understanding of the structure-function relationship allows for an optimized design of the molecular architecture with respect to possible applications, for example an optimized protein incorporation.
Authors:
Ann Junghans; Ingo Köper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  26     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11035-40     Citation Subset:  IM    
Affiliation:
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
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MeSH Terms
Descriptor/Qualifier:
Electrochemical Techniques
Lipid Bilayers / chemistry*
Models, Theoretical
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Lipid Bilayers

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