Document Detail

Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model.
MedLine Citation:
PMID:  23334238     Owner:  NLM     Status:  Publisher    
Aim:To investigate whether strontium ranelate (SR), a new antiosteoporotic agent, could attenuate cartilage degeneration and subchondral bone remodeling in osteoarthritis (OA).Methods:Medial meniscal tear (MMT) operation was performed in adult SD rats to induce OA. SR (625 or 1800 mg·kg(-1)·d(-1)) was administered via gavage for 3 or 6 weeks. After the animals were sacrificed, articular cartilage degeneration was evaluated using toluidine blue O staining, SOX9 immunohistochemistry and TUNEL assay. The changes in microarchitecture indices and tissue mineral density (TMD), chemical composition (mineral-to-collagen ratio), and intrinsic mechanical properties of the subchondral bones were measured using micro-CT scanning, confocal Raman microspectroscopy and nanoindentation testing, respectively.Results:The high-dose SR significantly attenuated cartilage matrix and chondrocyte loss at 6 weeks, and decreased chondrocyte apoptosis, improved the expression of SOX9, a critical transcription factor responsible for the expression of anabolic genes type II collagen and aggrecan, at both 3 and 6 weeks. Meanwhile, the high-dose SR also significantly attenuated the subchondral bone remodeling at both 3 and 6 weeks, as shown by the improved microarchitecture indices, TMD, mineral-to-collagen ratio and intrinsic mechanical properties. In contrast, the low-dose SR did not significantly change all the detection indices of cartilage and bone at both 3 and 6 weeks.Conclusion:The high-dose SR treatment can reduce articular cartilage degeneration and subchondral bone remodeling in the rat MMT model of OA.
De-Gang Yu; Hui-Feng Ding; Yuan-Qing Mao; Ming Liu; Bo Yu; Xin Zhao; Xiao-Qing Wang; Yang Li; Guang-Wang Liu; Shao-Bo Nie; Shen Liu; Zhen-An Zhu
Related Documents :
22971978 - Effects of sterilization and storage on the properties of alp-grafted biomaterials for ...
24054128 - Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for...
24038678 - Reconstruction of joint hyaline cartilage by autologous progenitor cells derived from e...
23333738 - Ex-vivo assessment and non-invasive in vivo imaging of internal hemorrhages in aga2/+ m...
24934318 - Association between low-frequency ultrasound and hip fractures - comparison with dxa-ba...
15188098 - Isolated liner exchange in revision total hip arthroplasty: clinical results using the ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  -     ISSN:  1745-7254     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Design, synthesis and biological evaluation of bivalent ligands against A(1)-D(1) receptor heteromer...
Next Document:  Assessment of the estrogenic activities of chickpea (Cicer arietinum L) sprout isoflavone extract in...