Document Detail


Strontium ranelate: a novel treatment in postmenopausal osteoporosis.
MedLine Citation:
PMID:  17308165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Strontium ranelate (SR) is a novel antiosteoporotic agent, electively concentrated in positions of active bone formation, and especially onto the crystal surface that allows permanent exchanges with extracellular fluid. Although the mechanism(s) of action is still under rigorous research, SR appears to reduce bone resorption by decreasing osteoclast differentiation and activity and to stimulate bone formation by increasing replication of preosteoblast cells, leading to increased matrix synthesis. In the placebo-controlled, phase III trial spinal osteoporosis therapeutic intervention (SOTI) (no=1442; mean age 69 years), there was a 41% decrease over 3 years in the number of patients with new vertebral fractures in the SR (2 g/day) group versus placebo (P<0.001), already detected after 12 months (49% lower risk, P<0.001). The phase III treatment of peripheral osteoporosis (TROPOS) study assessed the efficacy of SR (2 g/day) in preventing nonvertebral fractures in postmenopausal osteoporosis (no=4932; mean age 77 years). SR reduced nonvertebral fracture risk by 16% versus placebo (P=0.04) and hip fracture risk by 36% (P=0.031) in osteoporotic patients older than 74 years. Thus SR is an effective and safe treatment for vertebral and hip osteoporosis with a unique mode of action.
Authors:
S Tournis; D Economopoulos; G P Lyritis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1092     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-19     Completed Date:  2007-04-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-7     Citation Subset:  IM    
Affiliation:
Laboratory for Research of Musculoskeletal System Th. Garofalidis, University of Athens, KAT Hospital, 10 Athinas Str., Kifissia, PC: 14561, Athens, Greece. stournis@med.uoa.gr
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic
Female
Humans
Organometallic Compounds / administration & dosage,  therapeutic use*
Osteoporosis, Postmenopausal / prevention & control*
Thiophenes / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Organometallic Compounds; 0/Thiophenes; 0/strontium ranelate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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