| Strontium plaque irradiation of subfoveal neovascular membranes in age-related macular degeneration. | |
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MedLine Citation:
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PMID: 9457513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the effect of focal strontium-90 plaque radiotherapy on subfoveal choroidal neovascularization in patients with age-related macular degeneration. METHODS: Twenty patients with age-related macular degeneration, presenting with a recent subfoveal neovascular membrane, were treated with local episcleral radiotherapy using a strontium-90 applicator. The applicator was applied to the sclera under the macular region and held there tightly for 54 min to obtain a dose of 15 Gy at a depth of 1.75 mm. The main parameters evaluated at follow-up after 3, 6 and 12 months were visual acuity and changes in fluorescein angiography. Twelve untreated patients with the same criteria were followed as controls. RESULTS: Early effects of radiation could be seen at 3 months, but became more obvious after follow-up for 6 and 12 months. At 6 months, regression of the choroidal neovascularization was detected in 14/19 patients (74%) as a decrease in the size of the lesion or as diminished leakage in late-phase fluorescein angiography. Likewise, in 14/19 patients (74%) at 12 months the neovascular membrane was partially or totally occluded. In all patients showing regression of the choroidal neovascular membrane, the neurosensory detachment had also dried. Visual acuity was unchanged (within 1 line) or improved in 11/20 (55%) and 9/20 (45%) treated patients after 6 and 12 months, respectively. In the controls, the choroidal neovascularization had increased in size in 9/12 patients (75%) at the last follow-up (mean 12.0 months). Visual acuity was unchanged in 3/12 patients (25%). CONCLUSION: Local low-energy beta irradiation with a strontium-90 applicator can induce regression of choroidal neovascularization. The effect of irradiation is seen as a decrease in the size of the choroidal neovascular membrane and disappearance of the neurosensory detachment and exudates. |
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Authors:
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A Jaakkola; J Heikkonen; P Tommila; L Laatikainen; I Immonen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 236 ISSN: 0721-832X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-03-31 Completed Date: 1998-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 24-30 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Helsinki University Hospital, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Brachytherapy / instrumentation, methods* Choroid / blood supply*, pathology, radiation effects Dose-Response Relationship, Radiation Female Fluorescein Angiography Follow-Up Studies Fovea Centralis Fundus Oculi Humans Macular Degeneration / complications* Male Middle Aged Neovascularization, Pathologic / etiology, pathology, radiotherapy* Strontium Radioisotopes / therapeutic use* Treatment Outcome Visual Acuity |
| Chemical | |
Reg. No./Substance:
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0/Strontium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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