| Strontium hexaferrite nanomagnets suspended in a cosmetic preparation: a convenient tool to evaluate the biological effects of surface magnetism on human skin. | |
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MedLine Citation:
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PMID: 20637001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/PURPOSE: Magnetic therapy has been popular for ages, but its therapeutic abilities remain to be demonstrated. We aimed to develop a homogeneous, stable dispersion of magnetic nanoparticles in a skin-care preparation, as a tool to analyze the biological and physiological effects of superficial magnetism in skin. METHODS: SrFe(12)O(19) nanoparticles were generated by ultrasound, dispersed in glycerol, stabilized in Dermud cream and permanently magnetized. The magnetic cream was applied on the epidermis of human skin organ cultures. The effects on UV-induced cell toxicity, apoptosis and inflammatory cytokine expression were analyzed. A clinical test was performed to check skin moisturization. RESULTS: Nanomagnets were found to be homogenously and stably dispersed. After magnetization, the preparation generated a magnetic field of 1-2 G. Upon cream application, no cytotoxicity and no impairment of cellular vitality were found after 24 and 48 h, respectively. The anti-apoptotic and anti-inflammatory properties of Dermud were not modified, but its long-term effect on moisturization in vivo was slightly increased. CONCLUSION: Nanomagnetic Dermud cream can be used as a tool to analyze the biological effects of nanomagnets dispersed on the skin surface at the cellular and molecular levels, thus allowing to explore the possible therapeutic uses of superficial magnetism for skin care. |
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Authors:
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T Zioni; N Perkas; Y Wolfus; Y Soroka; I Popov; M Oron; I Perelshtein; Y Bruckental; F M Brégégère; Z Ma'or; A Gedanken; Y Yeshurun; R Neuman; Y Milner |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) Volume: 16 ISSN: 1600-0846 ISO Abbreviation: Skin Res Technol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504453 Medline TA: Skin Res Technol Country: Denmark |
Other Details:
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Languages: eng Pagination: 316-24 Citation Subset: IM |
Affiliation:
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Dead Sea and Arava Science Center, Dead Sea, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Complementary Therapies
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instrumentation*,
methods* Cosmetics / pharmacology Electric Capacitance / diagnostic use Electromagnetic Fields Emollients / pharmacology Ferric Compounds Humans Magnetics / instrumentation*, methods* Metal Nanoparticles Models, Theoretical Organ Culture Techniques Skin / radiation effects* Strontium |
| Chemical | |
Reg. No./Substance:
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0/Cosmetics; 0/Emollients; 0/Ferric Compounds; 1317-54-0/ferrite; 7440-24-6/Strontium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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