Document Detail

Strontium-89 chloride for pain palliation in prostatic skeletal malignancy.
MedLine Citation:
PMID:  1717094     Owner:  NLM     Status:  MEDLINE    
In a multi-centre study strontium-89 was shown to be effective in relieving bone pain from prostatic carcinoma in patients who had failed conventional therapies. Of 83 patients assessed at 3 months, following the administration of a dose of at least 1.5 MBq/kg, 75% derived benefit and 22% became pain free. Symptomatic improvement usually occurred within 6 weeks and continued for between 4 and 15 months (mean 6 months). Based on the dose estimation part of this study the recommended dose of strontium-89 is 150 MBq. Toxicity was low, provided platelet levels were above 100 x 10(9) l-1 at the time of treatment. Repeat treatments with strontium-89 may be given at intervals of not less than 3 months. Strontium-89 is administered intravenously on an out-patient basis with no special radiological protection precautions.
A H Laing; D M Ackery; R J Bayly; R B Buchanan; V J Lewington; A J McEwan; P M Macleod; M A Zivanovic
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  The British journal of radiology     Volume:  64     ISSN:  0007-1285     ISO Abbreviation:  Br J Radiol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-11-14     Completed Date:  1991-11-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  816-22     Citation Subset:  AIM; IM    
Department of Radiotherapy, Churchill Hospital, Oxford, UK.
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MeSH Terms
Bone Neoplasms / pathology,  radiotherapy,  secondary*
Palliative Care / methods*
Platelet Count / radiation effects
Prostatic Neoplasms / pathology*
Radiotherapy Dosage
Strontium / therapeutic use*
Strontium Radioisotopes / therapeutic use
Reg. No./Substance:
0/Strontium Radioisotopes; 10476-85-4/strontium chloride; 7440-24-6/Strontium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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