| Strontium-89 chloride for pain palliation in prostatic skeletal malignancy. | |
| | |
MedLine Citation:
|
PMID: 1717094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In a multi-centre study strontium-89 was shown to be effective in relieving bone pain from prostatic carcinoma in patients who had failed conventional therapies. Of 83 patients assessed at 3 months, following the administration of a dose of at least 1.5 MBq/kg, 75% derived benefit and 22% became pain free. Symptomatic improvement usually occurred within 6 weeks and continued for between 4 and 15 months (mean 6 months). Based on the dose estimation part of this study the recommended dose of strontium-89 is 150 MBq. Toxicity was low, provided platelet levels were above 100 x 10(9) l-1 at the time of treatment. Repeat treatments with strontium-89 may be given at intervals of not less than 3 months. Strontium-89 is administered intravenously on an out-patient basis with no special radiological protection precautions. |
| | |
Authors:
|
A H Laing; D M Ackery; R J Bayly; R B Buchanan; V J Lewington; A J McEwan; P M Macleod; M A Zivanovic |
Related Documents
:
|
1379924 - First canadian clinical study of transurethral hyperthermia in benign prostatic hyperpl... 9256324 - Influence of prostate size on terazosin efficacy. 8365444 - Quality of life after radical retropubic prostatectomy for carcinoma of the prostate. 10654894 - Pretreatment prostate-specific antigen as an outcome predictor of targeted transurethra... 11547294 - Low-dose postoperative aprotinin reduces mediastinal drainage and blood product use in ... 21282754 - Short- and long-term mortality following primary total hip replacement for osteoarthrit... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
|
Title: The British journal of radiology Volume: 64 ISSN: 0007-1285 ISO Abbreviation: Br J Radiol Publication Date: 1991 Sep |
Date Detail:
|
Created Date: 1991-11-14 Completed Date: 1991-11-14 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 816-22 Citation Subset: AIM; IM |
Affiliation:
|
Department of Radiotherapy, Churchill Hospital, Oxford, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bone Neoplasms
/
pathology,
radiotherapy,
secondary* Humans Male Palliative Care / methods* Platelet Count / radiation effects Prostatic Neoplasms / pathology* Radiotherapy Dosage Strontium / therapeutic use* Strontium Radioisotopes / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Strontium Radioisotopes; 10476-85-4/strontium chloride; 7440-24-6/Strontium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modulation of gastric contractions in response to tachykinins and bethanechol by extrinsic nerves.
Next Document: Cytokeratin shedding in urine as a biological marker for bladder cancer: monoclonal antibody-based e...