Document Detail


Strontium-85 in the fetuses of pregnant rats and mice.
MedLine Citation:
PMID:  3989286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnant SPF Wistar rats and ICR/Swiss albino mice were injected in the tail vein with 85SrCl2 with 0.05 mM inactive carrier (SrCl2) given in volumes of 0.1 ml. The activity in the injected volume was about 14 MBq per kg of rat and 13 MBq per kg of mouse. The animals were injected at 2 or 13 days of gestation. The activity retained by the fetuses was quantitatively determined at three stages of the fetal intrauterine development: in rats at 14, 16 and 21 days of gestation, in mice at 14, 16 and 20 days of gestation. The activity of fetuses and/or placentas with fetal membranes was measured using a TESLA automatic gamma counter. Results indicate that fetuses of mice retained a significantly (P less than 0.01) greater percent of strontium activity than fetuses of rats. The highest specific activities (the percentage of total activity retained per gram of fetal tissue) were found in the late pregnancy period (at 21 days of gestation in rats and 20 days of gestation in mice) in animals that were injected with the radionuclide at 13 days of gestation.
Authors:
Z Onyskowová; M Josífko
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hygiene, epidemiology, microbiology, and immunology     Volume:  29     ISSN:  0022-1732     ISO Abbreviation:  J Hyg Epidemiol Microbiol Immunol     Publication Date:  1985  
Date Detail:
Created Date:  1985-05-29     Completed Date:  1985-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985116R     Medline TA:  J Hyg Epidemiol Microbiol Immunol     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Extraembryonic Membranes / metabolism
Female
Fetus / metabolism*
Maternal-Fetal Exchange / radiation effects
Mice
Placenta / metabolism
Pregnancy
Rats
Rats, Inbred Strains
Strontium / pharmacology
Strontium Radioisotopes / metabolism*
Time Factors
Chemical
Reg. No./Substance:
0/Strontium Radioisotopes; 10476-85-4/strontium chloride; 7440-24-6/Strontium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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