| Strongyloidiasis in patients at a comprehensive cancer center in the United States. | |
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MedLine Citation:
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PMID: 15042689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The frequency of Strongyloides stercoralis infestation and complication in patients with cancer in the United States is unknown. METHODS: The authors performed a retrospective analysis of S. stercoralis infection in patients who were undergoing cancer treatment at The University of Texas M. D. Anderson Cancer Center (Houston, TX). RESULTS: The overall S. stercoralis infection frequency was approximately 1.0 per 10,000 new cancer cases between 1971 and 2003. Twenty-two of 25 patients (88%) were U.S. residents (19 from Texas; 1 each from Mississippi, Tennessee, and Puerto Rico), and the remaining 3 (13%) were from Latin America. Thirteen (52%) had solid-organ malignancies, whereas 12 (48%) had hematologic malignancies (lymphoma or multiple myeloma, n=8; leukemia, n=3; aplastic anemia, n=1). Twelve patients (48%) received systemic corticosteroids, 9 (36%) received antineoplastic therapy, and 2 underwent hematopoietic stem cell transplantation (HSCT). Diarrhea was reported in 13 patients (57%), and eosinophilia was observed in 11 patients (48%); 4 patients (16%) had probable hyperinfection syndrome (in 3 cases of polymicrobial gram-negative bacteremia, 1 patient had Klebsiella pneumoniae pneumonia, whereas 1 patient presented with K. pneumoniae lung infection alone). Evidence of definite pulmonary hyperinfection syndrome was observed in 2 HSCT recipients (8%). Fourteen (74%) of 19 patients responded to thiabendazole therapy. Two patients with definite pulmonary hyperinfection syndrome developed fatal S. stercoralis hemorrhagic alveolitis despite receiving high-dose thiabendazole plus ivermectin therapy. CONCLUSIONS: In the current study, strongyloidiasis was uncommon in patients with cancer and remained localized in individuals with solid-organ malignancies. Definite pulmonary accelerated autoinfections were observed only in HSCT recipients. Therefore, pre-HSCT S. stercoralis screening in individuals from endemic regions of the United States warrants further study. |
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Authors:
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Amar Safdar; Kumthorn Malathum; Saul J Rodriguez; Rola Husni; Kenneth V I Rolston |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer Volume: 100 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-25 Completed Date: 2004-05-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1531-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2004 American Cancer Society. |
Affiliation:
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Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA. asafdar@mdanderson.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antinematodal Agents / therapeutic use Bronchoalveolar Lavage Child Feces / parasitology Female Humans Male Middle Aged Neoplasms / complications*, parasitology Retrospective Studies Strongyloidiasis / complications, drug therapy, epidemiology* Thiabendazole / therapeutic use Treatment Outcome United States |
| Chemical | |
Reg. No./Substance:
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0/Antinematodal Agents; 148-79-8/Thiabendazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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