Document Detail

Strong reproductive isolation between humans and Neanderthals inferred from observed patterns of introgression.
MedLine Citation:
PMID:  21911389     Owner:  NLM     Status:  MEDLINE    
Recent studies have revealed that 2-3% of the genome of non-Africans might come from Neanderthals, suggesting a more complex scenario of modern human evolution than previously anticipated. In this paper, we use a model of admixture during a spatial expansion to study the hybridization of Neanderthals with modern humans during their spread out of Africa. We find that observed low levels of Neanderthal ancestry in Eurasians are compatible with a very low rate of interbreeding (<2%), potentially attributable to a very strong avoidance of interspecific matings, a low fitness of hybrids, or both. These results suggesting the presence of very effective barriers to gene flow between the two species are robust to uncertainties about the exact demography of the Paleolithic populations, and they are also found to be compatible with the observed lack of mtDNA introgression. Our model additionally suggests that similarly low levels of introgression in Europe and Asia may result from distinct admixture events having occurred beyond the Middle East, after the split of Europeans and Asians. This hypothesis could be tested because it predicts that different components of Neanderthal ancestry should be present in Europeans and in Asians.
Mathias Currat; Laurent Excoffier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-12
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  108     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-14     Completed Date:  2011-11-09     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15129-34     Citation Subset:  IM    
Anthropology, Genetics, and Peopling History Laboratory, Anthropology Unit, Department of Genetics and Evolution, University of Geneva, 1227 Geneva, Switzerland.
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MeSH Terms
Asian Continental Ancestry Group
Computer Simulation
European Continental Ancestry Group
Hominidae / physiology*
Hybridization, Genetic
Reproduction / physiology*

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