| Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients. | |
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MedLine Citation:
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PMID: 9488997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Linoleic acid is the most abundant fatty acid in human low density lipoproteins (LDL). Oxidation of LDL transforms linoleic acid to hydroperoxyderivatives. These are converted to 9-hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE). 9-HODE is much more abundant in oxidized LDL than other lipid peroxidation products and therefore an indicator of lipid peroxidation (LPO). In this study the 9-HODE content in the LDL of 19 obviously healthy volunteers and 17 atherosclerotic patients was investigated. The level of 9-HODE obtained from LDL of young atherosclerotic patients (aged 36-47 years) was increased by a factor of 20 when compared with samples from healthy volunteers of the same age group. The content of 9-HODE in the LDL of atherosclerotic patients aged between 69 and 94 years increased 30-100 fold when compared with young healthy individuals, but when compared with 'healthy' individuals of the same age group it was only 2-3 fold increased. Obviously, as individuals grow older LDL becomes more and more oxidized. Consequently, assuming that LDL oxidation is a precondition for atherosclerosis--older individuals will suffer from atherosclerosis, even if no easy detectable visible signs of this disease are recognizable. According to 9-HODE determination, the onset of the disease starts slowly in most individuals at around 50 years of age. |
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Authors:
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W Jira; G Spiteller; W Carson; A Schramm |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 91 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-03-27 Completed Date: 1998-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: IRELAND |
Other Details:
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Languages: eng Pagination: 1-11 Citation Subset: IM |
Affiliation:
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Lehrstuhl für Organische Chemie I, Universität Bayreuth, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteriosclerosis / metabolism* Female Humans Linoleic Acids / metabolism* Linoleic Acids, Conjugated* Lipid Peroxides / metabolism Lipoproteins, LDL / analysis*, metabolism Male Middle Aged Ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Linoleic Acids; 0/Linoleic Acids, Conjugated; 0/Lipid Peroxides; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 15514-85-9/9-hydroxy-10,12-octadecadienoic acid; 5204-88-6/13-hydroxy-9,11-octadecadienoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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