Document Detail

Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients.
MedLine Citation:
PMID:  9488997     Owner:  NLM     Status:  MEDLINE    
Linoleic acid is the most abundant fatty acid in human low density lipoproteins (LDL). Oxidation of LDL transforms linoleic acid to hydroperoxyderivatives. These are converted to 9-hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE). 9-HODE is much more abundant in oxidized LDL than other lipid peroxidation products and therefore an indicator of lipid peroxidation (LPO). In this study the 9-HODE content in the LDL of 19 obviously healthy volunteers and 17 atherosclerotic patients was investigated. The level of 9-HODE obtained from LDL of young atherosclerotic patients (aged 36-47 years) was increased by a factor of 20 when compared with samples from healthy volunteers of the same age group. The content of 9-HODE in the LDL of atherosclerotic patients aged between 69 and 94 years increased 30-100 fold when compared with young healthy individuals, but when compared with 'healthy' individuals of the same age group it was only 2-3 fold increased. Obviously, as individuals grow older LDL becomes more and more oxidized. Consequently, assuming that LDL oxidation is a precondition for atherosclerosis--older individuals will suffer from atherosclerosis, even if no easy detectable visible signs of this disease are recognizable. According to 9-HODE determination, the onset of the disease starts slowly in most individuals at around 50 years of age.
W Jira; G Spiteller; W Carson; A Schramm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  91     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-27     Completed Date:  1998-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Lehrstuhl für Organische Chemie I, Universität Bayreuth, Germany.
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MeSH Terms
Arteriosclerosis / metabolism*
Linoleic Acids / metabolism*
Linoleic Acids, Conjugated*
Lipid Peroxides / metabolism
Lipoproteins, LDL / analysis*,  metabolism
Middle Aged
Reg. No./Substance:
0/Linoleic Acids; 0/Linoleic Acids, Conjugated; 0/Lipid Peroxides; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 15514-85-9/9-hydroxy-10,12-octadecadienoic acid; 5204-88-6/13-hydroxy-9,11-octadecadienoic acid

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