Document Detail

Strong correlation between diet and development of colorectal cancer.
MedLine Citation:
PMID:  23276917     Owner:  NLM     Status:  MEDLINE    
Multiple factors have been described among the causes of non-hereditary colorectal cancer. In Western countries, the most common risk factors include upper-middle socioeconomic status and dietary regimens rich in proteins and animal fats. High consumption of red meats, smoked foods, cold cuts, or canned foods is believed to contribute to carcinogenesis as they directly affect epithlial turnover and cause metabolism of biliary acids. Dietary fibers have protective effects in that they capture the fats and biliary acids, thereby inhibiting their activity. Tobacco smoking acts both locally and systemically on the colorectal mucosa through the production of carcinogenic agents. Finally, the action of alcohol, in association with nicotine addiction, also increases the risk of developing colorectal tumors. Knowledge of dietary and environmental factors is of paramount importance in implementing preventive strategies for colorectal cancer.
Alessandro Cappellani; Antonio Zanghì; Maria Di Vita; Andrea Cavallaro; Gaetano Piccolo; Pierfrancesco Veroux; Emanuele Lo Menzo; Vincenzo Cavallaro; Paolo de Paoli; Massimiliano Veroux; Massimiliano Berretta
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-8     Citation Subset:  IM    
Department of Surgery, General Surgery and Breast Unit, University of Catania, Azienda Ospedaliero, Universitaria Policlinico, Vittorio Emanuele, via S. Sofia, 78 - 95123 Catania, Italy.
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MeSH Terms
Alcohol Drinking / adverse effects
Colitis / chemically induced
Colorectal Neoplasms / chemically induced,  etiology*,  prevention & control
Diet / adverse effects*
Dietary Fiber / administration & dosage
Epigenesis, Genetic
Fatty Acids, Unsaturated / administration & dosage
Folic Acid / therapeutic use
Glycemic Index
Insulin Resistance / physiology
Intestinal Mucosa / pathology
Meat / adverse effects
Obesity / complications
Smoking / adverse effects
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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