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Strong conservation of the bird Z chromosome in reptilian genomes is revealed by comparative painting despite 275 million years divergence.
MedLine Citation:
PMID:  21725690     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The divergence of lineages leading to extant squamate reptiles (lizards, snakes, and amphisbaenians) and birds occurred about 275 million years ago. Birds, unlike squamates, have karyotypes that are typified by the presence of a number of very small chromosomes. Hence, a number of chromosome rearrangements might be expected between bird and squamate genomes. We used chromosome-specific DNA from flow-sorted chicken (Gallus gallus) Z sex chromosomes as a probe in cross-species hybridization to metaphase spreads of 28 species from 17 families representing most main squamate lineages and single species of crocodiles and turtles. In all but one case, the Z chromosome was conserved intact despite very ancient divergence of sauropsid lineages. Furthermore, the probe painted an autosomal region in seven species from our sample with characterized sex chromosomes, and this provides evidence against an ancestral avian-like system of sex determination in Squamata. The avian Z chromosome synteny is, therefore, conserved albeit it is not a sex chromosome in these squamate species.
Authors:
Martina Pokorná; Massimo Giovannotti; Lukáš Kratochvíl; Fumio Kasai; Vladimir A Trifonov; Patricia C M O'Brien; Vincenzo Caputo; Ettore Olmo; Malcolm A Ferguson-Smith; Willem Rens
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-2
Journal Detail:
Title:  Chromosoma     Volume:  -     ISSN:  1432-0886     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985138R     Medline TA:  Chromosoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Faculty of Science, Charles University in Prague, Viničná 7, 128 44, Prague 2, Czech Republic.
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