Document Detail

Stromal myofibroblasts in squamous cell carcinoma of the tongue in young patients - a multicenter collaborative study.
MedLine Citation:
PMID:  25240996     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The purpose of this study was to evaluate the presence of myofibroblasts, frequently associated with a more aggressive neoplastic behavior, in oral tongue squamous cell carcinoma (TSCC) of young patients and to compare with the distribution observed in older patients.
STUDY DESIGN: Tumor samples from 29 patients younger than 40 years old affected by TSCC were retrieved and investigated for the presence of stromal myofibroblasts by immunohistochemical reactions against α smooth muscle actin, and the results obtained were compared to TSCC cases affecting older patients.
RESULTS: No positive reaction could be found in the stromal areas devoid of neoplastic tissue, whereas myofibroblasts were present in 58.6% of the lesions in young patients and in 75.9% of the older ones. No significant difference was found when comparing the invasive front and the overall stroma of both groups, and no correlation could be obtained with stromal α smooth muscle actin expression, higher tumor grades or clinical stage (P > .05).
CONCLUSION: There was no significant difference between the presence of stromal myofibroblasts of TSCC affecting young and old individuals.
Felipe Paiva Fonseca; Ricardo Della Coletta; Marina Barbosa Azevedo; Ana Carolina Prado Ribeiro; Ana Maria Pires Soubhia; Glauco Issamu Miyahara; Roman Carlos; Paula Farthing; Keith D Hunter; Paul M Speight; Pablo Agustin Vargas; Oslei Paes Almeida; Marcio Ajudarte Lopes; Alan Roger Santos-Silva
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Publication Detail:
Type:  Journal Article     Date:  2014-08-02
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  118     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-09-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  483-9     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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