Document Detail


Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity.
MedLine Citation:
PMID:  23278748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secondary lymphoid organs (SLOs), including lymph nodes, Peyer's patches, and the spleen, have evolved to bring cells of the immune system together. In these collaborative environments, lymphocytes scan the surfaces of antigen-presenting cells for cognate antigens, while moving along stromal networks. The cell-cell interactions between stromal and hematopoietic cells in SLOs are therefore integral to the normal functioning of these tissues. Not only do stromal cells physically construct SLO architecture but they are essential for regulating hematopoietic populations within these domains. Stromal cells interact closely with lymphocytes and dendritic cells, providing scaffolds on which these cells migrate, and recruiting them into niches by secreting chemokines. Within lymph nodes, stromal cell-ensheathed conduit networks transport small antigens deep into the SLO parenchyma. More recently, stromal cells have been found to induce peripheral CD8(+) T-cell tolerance and control the extent to which newly activated T cells proliferate within lymph nodes. Thus, stromal-hematopoietic crosstalk has important consequences for regulating immune cell function within SLOs. In addition, stromal cell interactions with hematopoietic cells, other stroma, and the inflammatory milieu have profound effects on key stromal functions. Here, we examine ways in which these interactions within the lymph node environment influence the adaptive immune response.
Authors:
Deepali Malhotra; Anne L Fletcher; Shannon J Turley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  251     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-28     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  160-76     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity*
Animals
Antigen Presentation
Cell Communication / immunology
Cell Movement / immunology
Chemokines / immunology
Hematopoietic Stem Cells / immunology*
Humans
Lymph Nodes / immunology*
Lymphocyte Activation
Stromal Cells / immunology
Grant Support
ID/Acronym/Agency:
P01 AI045757/AI/NIAID NIH HHS; P01 AI045757/AI/NIAID NIH HHS; R01 DK074500/DK/NIDDK NIH HHS; R01 DK074500/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Chemokines
Comments/Corrections

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