| Stromal-epithelial communications in hyperplastic human endometrium. | |
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MedLine Citation:
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PMID: 8166189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our objective was to assess the cell-to-cell contacts in hyperplastic human endometrium and to compare them with contacts in normal endometrium. STUDY DESIGN: Hyperplastic endometrial samples (five with simple hyperplasia and five with complex hyperplasia) without atypia by light microscopy were studied with transmission electron microscopy. The cell-to-cell contacts, basal lamina, and epithelial-to-stromal compartment contacts were studied and compared with these same areas in normal endometrium. RESULTS: Only infrequent gap junctions between epithelial cells were seen. Other epithelial contacts were also greatly reduced when compared with normal epithelium. Cell-to-cell contacts between the epithelial compartment and the stromal compartment were rare and degenerative in configuration. An increase in extracellular matrix and various alterations in the basal lamina appears to contribute to a decrease in cell-to-cell contacts. CONCLUSIONS: Compared with normal endometrium, hyperplastic endometrium demonstrated far fewer cell-to-cell contacts. The basal lamina and extracellular matrix were altered in such a fashion that communication between the stromal and epithelial compartments appeared to be impaired. Stromal and epithelial cells rarely were in contact. Those contacts present were less complex and the majority were degenerative. Hyperplasia without atypia demonstrated a much lower amount of intercellular communication than normal endometrium. |
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Authors:
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D V Horbelt; T H Parmley; D K Roberts; N J Walker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 170 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-05-26 Completed Date: 1994-05-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1061-70; discussion 1070-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Kansas School of Medicine-Wichita, HCA-Wesley Medical Center 67214-4976. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Communication* Endometrial Hyperplasia / pathology* Endometrium / ultrastructure* Epithelium / ultrastructure Female Humans Microscopy, Electron Stromal Cells / ultrastructure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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