| Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. | |
| | |
MedLine Citation:
|
PMID: 17112751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
After entry into lymph nodes (LNs), B cells migrate to follicles, whereas T cells remain in the paracortex, with each lymphocyte type showing apparently random migration within these distinct areas. Other than chemokines, the factors contributing to this spatial segregation and to the observed patterns of lymphocyte movement are poorly characterized. By combining confocal, electron, and intravital microscopy, we showed that the fibroblastic reticular cell network regulated naive T cell access to the paracortex and also supported and defined the limits of T cell movement within this domain, whereas a distinct follicular dendritic cell network similarly served as the substratum for movement of follicular B cells. These results highlight the central role of stromal microanatomy in orchestrating cell migration within the LN. |
| | |
Authors:
|
Marc Bajénoff; Jackson G Egen; Lily Y Koo; Jean Pierre Laugier; Frédéric Brau; Nicolas Glaichenhaus; Ronald N Germain |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2006-11-16 |
Journal Detail:
|
Title: Immunity Volume: 25 ISSN: 1074-7613 ISO Abbreviation: Immunity Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2006-12-18 Completed Date: 2007-02-07 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
|
Languages: eng Pagination: 989-1001 Citation Subset: IM |
Affiliation:
|
Lymphocyte Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adoptive Transfer Animals Cell Communication / immunology Chemotaxis, Leukocyte / immunology* Diagnostic Imaging Immunohistochemistry Lymph Nodes / immunology, metabolism, ultrastructure* Lymphocytes / cytology, immunology, metabolism* Mice Mice, Inbred C57BL Microscopy, Confocal Microscopy, Electron, Scanning Microscopy, Electron, Transmission Stromal Cells / immunology, ultrastructure* |
| Grant Support | |
ID/Acronym/Agency:
|
Z01 AI000545-19/AI/NIAID NIH HHS |
| Comments/Corrections | |
Comment In:
|
Immunity. 2006 Dec;25(6):867-9
[PMID:
17174930
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neural correlates of a 'pessimistic' attitude when anticipating events of unknown emotional valence.
Next Document: Co-sleeping, an ancient practice: issues of the past and present, and possibilities for the future.