Document Detail

Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes.
MedLine Citation:
PMID:  17112751     Owner:  NLM     Status:  MEDLINE    
After entry into lymph nodes (LNs), B cells migrate to follicles, whereas T cells remain in the paracortex, with each lymphocyte type showing apparently random migration within these distinct areas. Other than chemokines, the factors contributing to this spatial segregation and to the observed patterns of lymphocyte movement are poorly characterized. By combining confocal, electron, and intravital microscopy, we showed that the fibroblastic reticular cell network regulated naive T cell access to the paracortex and also supported and defined the limits of T cell movement within this domain, whereas a distinct follicular dendritic cell network similarly served as the substratum for movement of follicular B cells. These results highlight the central role of stromal microanatomy in orchestrating cell migration within the LN.
Marc Bajénoff; Jackson G Egen; Lily Y Koo; Jean Pierre Laugier; Frédéric Brau; Nicolas Glaichenhaus; Ronald N Germain
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2006-11-16
Journal Detail:
Title:  Immunity     Volume:  25     ISSN:  1074-7613     ISO Abbreviation:  Immunity     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-02-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  989-1001     Citation Subset:  IM    
Lymphocyte Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Adoptive Transfer
Cell Communication / immunology
Chemotaxis, Leukocyte / immunology*
Diagnostic Imaging
Lymph Nodes / immunology,  metabolism,  ultrastructure*
Lymphocytes / cytology,  immunology,  metabolism*
Mice, Inbred C57BL
Microscopy, Confocal
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Stromal Cells / immunology,  ultrastructure*
Grant Support
Z01 AI000545-19/AI/NIAID NIH HHS
Comment In:
Immunity. 2006 Dec;25(6):867-9   [PMID:  17174930 ]

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