| Stromal cell-derived factor-1 promotes migration of cells from the upper rhombic lip in cerebellar development. | |
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MedLine Citation:
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PMID: 20568288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During cerebellar development, the chemokine stromal cell-derived factor-1 alpha (SDF-1 alpha) has been shown to play an important role in recruiting cells from the upper rhombic lip (URL) and external granule cell layer (EGL). However, its function in cerebellar development is still poorly understood. Our results have demonstrated that SDF-1 is necessary for EGL development, and URL cells stream to the SDF-1 source in vitro. Results of embryonic URL explant assays and transwell assays indicated that SDF-1 induces neural cell migration from the URL region in chemotactic and chemokinetic responses. The time-lapse results showed that the migration speed of granule cell progenitors out of the URL was accelerated by the addition of recombinant SDF-1 alpha. Collectively, our study shows that SDF-1 increases the motility of URL cells in the absence of a gradient and promotes the migration of granule cell progenitors during cerebellar development. |
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Authors:
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Tao Yu; Hai Huang; Hui-Fang Li |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroscience research Volume: 88 ISSN: 1097-4547 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: United States |
Other Details:
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Languages: eng Pagination: 2775-86 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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School of Life Sciences, Shanghai University, Shanghai, People's Republic of China. emmayu@staff.shu.edu.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Animals, Newborn Cell Line, Transformed Cell Movement / drug effects, genetics, physiology* Cerebellum* / cytology, embryology, growth & development Chemokine CXCL12 / deficiency*, pharmacology Coculture Techniques / methods Embryo, Mammalian Eye Proteins / metabolism Homeodomain Proteins / metabolism Humans Mice Mice, Transgenic Neurons / drug effects, physiology* Organ Culture Techniques Paired Box Transcription Factors / metabolism Repressor Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CXCL12; 0/Eye Proteins; 0/Homeodomain Proteins; 0/PAX6 protein; 0/Paired Box Transcription Factors; 0/Repressor Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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