Document Detail

Stromal cell-derived factor-1 promotes migration of cells from the upper rhombic lip in cerebellar development.
MedLine Citation:
PMID:  20568288     Owner:  NLM     Status:  MEDLINE    
During cerebellar development, the chemokine stromal cell-derived factor-1 alpha (SDF-1 alpha) has been shown to play an important role in recruiting cells from the upper rhombic lip (URL) and external granule cell layer (EGL). However, its function in cerebellar development is still poorly understood. Our results have demonstrated that SDF-1 is necessary for EGL development, and URL cells stream to the SDF-1 source in vitro. Results of embryonic URL explant assays and transwell assays indicated that SDF-1 induces neural cell migration from the URL region in chemotactic and chemokinetic responses. The time-lapse results showed that the migration speed of granule cell progenitors out of the URL was accelerated by the addition of recombinant SDF-1 alpha. Collectively, our study shows that SDF-1 increases the motility of URL cells in the absence of a gradient and promotes the migration of granule cell progenitors during cerebellar development.
Tao Yu; Hai Huang; Hui-Fang Li
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  88     ISSN:  1097-4547     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2775-86     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
School of Life Sciences, Shanghai University, Shanghai, People's Republic of China.
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MeSH Terms
Analysis of Variance
Animals, Newborn
Cell Line, Transformed
Cell Movement / drug effects,  genetics,  physiology*
Cerebellum* / cytology,  embryology,  growth & development
Chemokine CXCL12 / deficiency*,  pharmacology
Coculture Techniques / methods
Embryo, Mammalian
Eye Proteins / metabolism
Homeodomain Proteins / metabolism
Mice, Transgenic
Neurons / drug effects,  physiology*
Organ Culture Techniques
Paired Box Transcription Factors / metabolism
Repressor Proteins / metabolism
Reg. No./Substance:
0/Chemokine CXCL12; 0/Eye Proteins; 0/Homeodomain Proteins; 0/PAX6 protein; 0/Paired Box Transcription Factors; 0/Repressor Proteins

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