Document Detail

Strokes in paroxysmal atrial fibrillation have more favorable outcome than in permanent atrial fibrillation.
MedLine Citation:
PMID:  18976324     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our aim was to compare the course of IS due to ptAF and pxAF. METHODS: A prospective, single-center study was conducted in patients with AF and acute IS with 6-month follow-up. RESULTS: We included 178 patients: 70 (39%) with pxAF and 108 (61%) with ptAF. Compared with patients with ptAF, patients with pxAF more often presented with subcortical, mainly lacunar strokes (21% vs 8%, P = 0.01) and were less frequently dependent at discharge (16% vs 42%, P < 0.001) and after 6 months (16% vs 20%, P < 0.001). Strokes in patients with pxAF were more frequently categorized as non-cardioembolic (35% vs 18%, P = 0.01). In the multivariate analysis, after adjustment for confounding factors (diabetes, chronic heart failure, high risk of thromboembolism and lack of prestroke anticoagulation), ptAF was an important risk factor for unfavorable short-term (OR 5.4; P < 0.01) and long-term outcomes (OR 2.6, P = 0.01) of IS. In all patients with AF, the occurrence of non-cardioembolic stroke was related to a reduced risk of dependence or death in short-term outcome (OR 0.4, P = 0.04) and marginally influenced long-term outcome (OR 0.49, P = 0.09). CONCLUSIONS: The present study suggests that, compared with patients with ptAF, ISs in patients with pxAF have better outcomes.
J Staszewski; B Brodacki; K Tomczykiewicz; J Kotowicz; A Stepien
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-10-22
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  119     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-21     Completed Date:  2009-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  IM    
Department of Neurology, Military Medical Institute, Warsaw, Poland.
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MeSH Terms
Acute Disease / epidemiology
Aged, 80 and over
Atrial Fibrillation / complications*,  mortality,  physiopathology
Brain Infarction / epidemiology,  physiopathology,  therapy
Chronic Disease / epidemiology
Cohort Studies
Follow-Up Studies
Outcome Assessment (Health Care) / methods
Poland / epidemiology
Prospective Studies
Risk Factors
Stroke / diagnosis*,  etiology,  mortality
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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