| Strokes in paroxysmal atrial fibrillation have more favorable outcome than in permanent atrial fibrillation. | |
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MedLine Citation:
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PMID: 18976324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our aim was to compare the course of IS due to ptAF and pxAF. METHODS: A prospective, single-center study was conducted in patients with AF and acute IS with 6-month follow-up. RESULTS: We included 178 patients: 70 (39%) with pxAF and 108 (61%) with ptAF. Compared with patients with ptAF, patients with pxAF more often presented with subcortical, mainly lacunar strokes (21% vs 8%, P = 0.01) and were less frequently dependent at discharge (16% vs 42%, P < 0.001) and after 6 months (16% vs 20%, P < 0.001). Strokes in patients with pxAF were more frequently categorized as non-cardioembolic (35% vs 18%, P = 0.01). In the multivariate analysis, after adjustment for confounding factors (diabetes, chronic heart failure, high risk of thromboembolism and lack of prestroke anticoagulation), ptAF was an important risk factor for unfavorable short-term (OR 5.4; P < 0.01) and long-term outcomes (OR 2.6, P = 0.01) of IS. In all patients with AF, the occurrence of non-cardioembolic stroke was related to a reduced risk of dependence or death in short-term outcome (OR 0.4, P = 0.04) and marginally influenced long-term outcome (OR 0.49, P = 0.09). CONCLUSIONS: The present study suggests that, compared with patients with ptAF, ISs in patients with pxAF have better outcomes. |
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Authors:
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J Staszewski; B Brodacki; K Tomczykiewicz; J Kotowicz; A Stepien |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-10-22 |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 119 ISSN: 1600-0404 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-21 Completed Date: 2009-06-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 325-31 Citation Subset: IM |
Affiliation:
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Department of Neurology, Military Medical Institute, Warsaw, Poland. staszej@amwaw.edu.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease
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epidemiology Aged Aged, 80 and over Atrial Fibrillation / complications*, mortality, physiopathology Brain Infarction / epidemiology, physiopathology, therapy Chronic Disease / epidemiology Cohort Studies Comorbidity Female Follow-Up Studies Humans Male Outcome Assessment (Health Care) / methods Poland / epidemiology Prospective Studies Risk Factors Stroke / diagnosis*, etiology, mortality Survival Rate Treatment Outcome |
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