Document Detail

Stroke-work loss underestimates hemodynamic significance of aortic stenosis in patients with hypertension.
MedLine Citation:
PMID:  17651094     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Stroke-work loss (SWL) represents the amount of energy the left ventricle dissipates as heat because of outflow obstruction. Recent studies suggest that SWL > 25% was the most clinically efficient Doppler measure for predicting hemodynamic significance, symptomatic status, and outcome in patients with aortic stenosis (AS). However, SWL may be affected by systolic blood pressure (SBP). OBJECTIVE: To determine if SWL reliably predicts hemodynamic significance of AS in patients with hypertension. METHODS: We studied 42 consecutive patients with hemodynamically significant AS requiring aortic valve replacement (AVR). Data on demographics, preoperative hemodynamics, and echocardiographic parameters were obtained. SWL was measured using the formula SWL = 100 x mean PG/ (mean PG + SBP), where PG is transaortic pressure gradient. Patients were considered hypertensive if their BP > 140/90 mmHg or if they are on antihypertensive medications. RESULTS: There were 27 males (64%) and mean age was 68 +/- 11 years. Twenty-four patients (57%) were hypertensive. Mean SBP was 134 +/- 24 mmHg, mean transaortic PG 47 +/- 20 mmHg, effective valve orifice area (EOA) by Doppler estimation 0.74 +/- 0.23 cm(2), and SWL 26 +/- 9%. Patients with hypertension had smaller SWL than normotensives (table I). SWL was >25% in 20 (49%) patients, and fewer patients with hypertension have SWL >25% (33% vs 71%, P = 0.019). Of note, patients with SWL < or =25% had significantly higher SBP (145 +/- 21 mmHg vs 122 +/- 22 mmHg, P = 0.02). CONCLUSION: SWL underestimates the hemodynamic significance of aortic stenosis in the majority of patients with hypertension.
Raymond Ching-Chiew Wong; Tiong Cheng Yeo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  24     ISSN:  0742-2822     ISO Abbreviation:  Echocardiography     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  673-6     Citation Subset:  IM    
The Cardiac Department, National University Hospital, Singapore.
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MeSH Terms
Aortic Valve Stenosis / complications*,  ultrasonography*
Echocardiography, Doppler / methods*
Reproducibility of Results
Sensitivity and Specificity
Stroke Volume
Ventricular Outflow Obstruction / complications*,  ultrasonography*

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