Document Detail

Stroke vs. chronic progressive cerebrovascular disease: a magnetic resonance imaging study of symptomatic outpatients.
MedLine Citation:
PMID:  12417359     Owner:  NLM     Status:  MEDLINE    
Stroke is the main manifestation of cerebrovascular disease (CVD). Few studies report the insidious and progressive development of CVD. The aim of this study was the characterization of a CVD form without stroke in association with vascular subtypes and risk factors (VRF). From 105 CVD patients, 65 had stroke (62%), 13 of them had more than one stroke (20%), and 40 patients had a chronic progressive form (CPF) (38%). Mean evolution times up to maximum neurological deficiency were 1.57+/-0.94 and 344.25+/-210.96 days, respectively. Group results significantly associated with VRFs: hypertension (p=0.0046), hyperlipemia (p=0.0046) and atrial fibrillation (p=0.0173); with clinical manifestations: aphasia (p=0.0018), pyramidal syndrome (p=0.0000001) and small vessel disease (SVD) (p=0.0000001); and with MRI: bilateral infarctions (p=0.00009) and incomplete white matter lesions (IWMLs) (p=0.0061). Within the CPF group, dysarthria and complete infarctions were associated (p=0.00036). Most neurological disorders associated with CVD are related to CPF. The significant correlations of SVD, bilateral infarcts, IWMLs, dysarthria, several VRFs and the strong difference in evolution time up to maximum neurological deficiency values characterize CPF as a separate entity within CVD.
Raúl O Domínguez; Enrique R Marschoff; Jorge A Serra; Alberto Gallo; Eduardo L Bartolomé; Silvia González; Graciela D'Abbraccio; Eleonora Bagg; José Vila; Arturo L Famulari
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  203-204     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-05     Completed Date:  2003-01-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
Hospital Sirio-Libanés, Servicio de Neurología, Cátedra de Neurología Universidad de Buenos Aires, Buenos Aires, Argentina.
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MeSH Terms
Cerebrovascular Disorders / pathology*,  psychology*
Chronic Disease
Disease Progression
Magnetic Resonance Imaging
Neuropsychological Tests
Prospective Studies
Risk Factors
Stroke / etiology,  pathology*,  psychology*

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