Document Detail

Stroke recovery and sensory plasticity: common mechanisms?
MedLine Citation:
PMID:  22415919     Owner:  NLM     Status:  MEDLINE    
Presentations in this symposium are considered in the context of mechanisms of sensory plasticity, particularly in the auditory system. The auditory nervous system has two discrete end organs that are separately vulnerable to clinical and experimental injury, and brainstem processing mechanisms that are highly specialized for temporal, spectral, and spatial coding. These include giant axo-somatic synapses and neurons with spatially segregated bipolar dendrites, each innervated exclusively from one ear. This architecture allows exquisite control of afferent-target interactions, including known excitatory and inhibitory couplings, and consequently enhanced interpretation of data from other brain systems. For example, deafening can silence the auditory nerve, but has surprisingly little impact on normal brain function, as evidenced by the success of cochlear implants. The observed amplification from one brain region to another of degeneration following stroke or discrete brain lesions may thus be due to secondary rather than primary afferent consequences of the lesion.
David R Moore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Developmental psychobiology     Volume:  54     ISSN:  1098-2302     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-14     Completed Date:  2012-07-16     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  326-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Auditory Pathways / physiopathology*
Brain / physiopathology*
Cochlear Nerve / physiopathology
Hearing Loss / physiopathology*
Neuronal Plasticity / physiology*
Neurons / physiology
Recovery of Function / physiology*
Stroke / physiopathology*
Grant Support
MC_U135097130//Medical Research Council; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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