Document Detail

Stroke prophylaxis in nonvalvular atrial fibrillation.
MedLine Citation:
PMID:  11176219     Owner:  NLM     Status:  MEDLINE    
Nonvalvular atrial fibrillation is the most prevalent dysrrhythmia, and carries with it an at least fivefold increased risk of ischaemic stroke. Currently, the implementation and optimization of prophylactic therapy (with warfarin or acetylsalicylic acid) is the most effective approach, at the population level, to optimize outcomes in patients with atrial fibrillation. Therefore, clinical trial evidence regarding warfarin and acetylsalicylic acid in stroke prophylaxis is highlighted. Recently, considerable data have emerged that indicate suboptimal use of warfarin in clinical practice (both in terms of the prescription and titration of therapy). Narrowing this gap between research evidence and clinical practice may be accomplished by identifying those patients who are eligible for prophylaxis, and then maintaining them at an adequate level of anticoagulation.
T J Bungard; A Shuaib; R T Tsuyuki
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  14     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-05     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
EPICORE Centre, Division of Cardiology, Cardiology, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Anticoagulants / therapeutic use
Atrial Fibrillation / drug therapy*
Brain Ischemia / etiology
Preventive Medicine / methods
Randomized Controlled Trials as Topic
Risk Factors
Stroke / drug therapy,  etiology,  prevention & control*
Reg. No./Substance:

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