| Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia. | |
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MedLine Citation:
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PMID: 16946159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Bacterial pneumonia is the most common cause of death in patients sustaining acute stroke and is believed to result from an increased aspiration. Recently, stroke-induced immunodeficiency was described in a mouse model of cerebral ischemia, which is primarily caused by overactivation of sympathetic nervous system. We tested if stroke-induced immunodeficiency increases the risk of pneumonia after aspiration in a newly developed model of poststroke pneumonia. METHODS: Experimental stroke in mice was induced by occlusion of the middle cerebral artery (MCAO) for 60 minutes. Aspiration pneumonia was induced by intranasal application of 20 microL of a defined suspension of Streptococcus pneumoniae in phosphate-buffered saline 4 or 14 days after MCAO. Treatment comprised moxifloxacin (100 mg/kg body weight, six times every 2 hours after operation) or propranolol (30 mg/kg body weight, immediately before as well as 4 and 8 hours after MCAO). Readout was lung histology and bacterial counts in lung and blood. RESULTS: Nasal inoculation of only 200 colony-forming units of S. pneumoniae caused severe pneumonia and bacteremia after experimental stroke, whereas 200,000 colony-forming units are needed to induce comparable disease in sham animals. Aspiration pneumonia in stroke animals outlasted acute stroke state but was preventable by beta-adrenoreceptor blockade. CONCLUSIONS: Experimental stroke propagates bacterial aspiration from harmless intranasal colonization to harmful pneumonia. Prevention of infections by beta-adrenoreceptor blockade suggests that immunodepression by sympathetic hyperactivity is essential for progression of bacterial aspiration to pneumonia. |
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Authors:
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Konstantin Prass; Johann S Braun; Ulrich Dirnagl; Christian Meisel; Andreas Meisel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-08-31 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 37 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-26 Completed Date: 2006-10-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2607-12 Citation Subset: IM |
Affiliation:
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Department of Experimental Neurology, Charité Universitaetsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Intranasal Adrenergic beta-Antagonists / therapeutic use Animals Bacteremia / etiology Catecholamines / physiology Disease Progression Disease Susceptibility Female Immunologic Deficiency Syndromes / etiology*, physiopathology, prevention & control Infarction, Middle Cerebral Artery / complications*, immunology Inhalation* Male Mice Nasal Cavity / microbiology Pneumonia, Bacterial / etiology* Pneumonia, Pneumococcal / etiology Specific Pathogen-Free Organisms Streptococcus pneumoniae Stroke / complications*, immunology Sympathetic Nervous System / drug effects, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Catecholamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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