Document Detail

Stroke-prone spontaneously hypertensive rats as a model for toxemia of pregnancy and aggravating and preventive effects of maternal modifications during pregnancy on offspring's growth.
MedLine Citation:
PMID:  2232119     Owner:  NLM     Status:  MEDLINE    
Genetical differences in changes in blood pressure (BP) were chronologically investigated during pregnancy in stroke-prone spontaneously hypertensive rats (SHRSP), Wistar-Kyoto rats (WKY) and Sprague-Dawley (SD) rats. Especially, the early stages were carefully studied. Maternal conditions in SHRSP were modified by the treatments with NaCl and taurine, respectively. BP in SHRSP and WKY rose significantly at the early stage of pregnancy compared to prepregnancy levels (SHRSP; 208 +/- 2 mmHg vs 197 +/- 5 mmHg, WKY; 133 +/- 2 mmHg vs 126 +/- 1 mmHg) (p less than 0.05). In contrast, no such changes were observed in SD rats. Differences in 24-hour urinary epinephrine excretion before and during pregnancy ran parallel with such BP changes among these strains. NaCl-loaded SHRSP died during pregnancy with severe pathohistological changes in their kidneys and severe proteinuria. Taurine treatment had a marked prophylactic effect on these maternal pathological changes during pregnancy, resulting in better growth in offsprings. These results suggest that SHRSP could be one of the suitable animal models for the studies on toxemia of pregnancy and also suggest an important role of hypertensive genetical disposition in the development of toxemia of pregnancy.
T Shibukawa; R Horie; M Kitao; Y Yamori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  54     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-12-13     Completed Date:  1990-12-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  644-52     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
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MeSH Terms
Birth Weight
Blood Pressure*
Cerebrovascular Disorders
Disease Models, Animal
Embryonic and Fetal Development
Pre-Eclampsia / physiopathology*
Pregnancy Complications, Cardiovascular / physiopathology*
Rats, Inbred SHR
Rats, Inbred Strains
Rats, Inbred WKY
Taurine / pharmacology
Reg. No./Substance:

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